Outline of our laboratory


The objective of this laboratory is to design and create novel biocompatible materials on the basis of molecular-level analysis of living body/material interactions and mechanism of biocompatibility. Furthermore, investigations applicable to the development of novel artificial organs, such as artificial skin, artificial bone, artificial nerve, and so on; novel therapeutic methods; novel drugs; and novel drug delivery systems are made. Then, the results and knowledge are made feedback to the analysis of living body/material interactions and to the design for novel biocompatible materials. Therefore, education and research of this laboratory are made in accordance with the triangular strategy as illustrated in Figure 1, and aim at creating a useful material to improve quality of medicine and life.

Fig.1. Triangular Research Strategies.

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The major feature of this laboratory is creation of intelligent materials using new bioabsorbable polymers, bioactive peptides, bioactive ceramics, and their hybrids. For example, temperature-sensitive aggregation of a novel biodegradable polyamide is shown in Figure 2. Though this biodegradable polyamide dissolves in water at rt, it aggregates at 37ūC in a reversible mode. The polyamide shows high safety, because it consists of non-toxic low molecular weight substances and biodegradable amide bonds. It may be useful in the construction of materials for temperature-responsible drug release systems, tissue adhesives, and wound dressings. For another example, Figure 3 shows ectopic bone formation observed in alginate hydrogel linked with BMP-2-derived peptide. This material may be useful for bone regenration.

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Fig. 2. A Novel Temperature-Sensitive Polyamide.

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Fig. 3. Material for Bone Regeneration.

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