NAIST Graduate School of Materials Science

Biocompatible Materials Science Laboratory

Staff & Contact
Educational StaffProf. Masao Tanihara
Associate Prof. Tsuyoshi Ando
Assistant Prof. Kayo Terada, Mime Kobayashi
ContactTEL: +81-743-72-6120
URLhttp://mswebs.naist.jp/LABs/tanihara/index-e.html

The Biocompatible Materials Science Laboratory is working on analyzing the interaction between living organisms and materials at the molecular level to elucidate biocompatibility mechanisms, applying the findings to the development of materials for regenerative medicine such as those for the nerve, blood vessels, bones, and skin, as well as the development of new treatments, drugs, and drug delivery systems (DDS). In the laboratory, we offer study meetings once a week on subjects in the fields of chemistry, organic chemistry, biochemistry, instrumental analyses, and polymer science so that students can learn and conduct research in a wide range of areas. We take advantage of knowledge and technology in various academic disciplines including organic chemistry, inorganic chemistry, polymer science, molecular biology, medicine, and pharmaceutical sciences, to conduct molecular design and evaluation of new materials. Furthermore, we hold weekly journal meetings, monthly report meetings, and interim report meetings twice a year. Through these research and educational activities, we aim to foster researchers who can play a leading role in functional materials research.

Based on the analysis of biocompatibility mechanisms, we are developing materials for regenerative medicine such as those for nerves, blood vessels, bone, skin, as well as developing new treatments, drugs, and drug delivery systems (DDS). Specifically, we are advancing our research in the following fields: the elucidation of biocompatibility mechanisms, the design and creation of materials that support tissue engineering and regenerative medicine, and the development of a synthetic vector for gene therapy. For the elucidation of biocompatibility mechanisms, the interaction between biological (genes, proteins, cells, tissues, and individual organisms) and synthetic materials are analyzed at the molecular level. The discovery and basic knowledge obtained will be utilized for designing new materials. For example, we are developing innovative antithrombogenic materials that enable small-bore artificial blood vessels that have not been achieved by conventional technology.

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1. Kusumastuti Y, Shibasaki Y, Hirohara S, Kobayashi M, Terada K, Ando T, Tanihara M; “Encapsulation of rat bone marrow stromal cells using a polyion complex gel of chitosan and succinylated poly(Pro-Hyp-Gly) ” J Tissue Eng Regen Med, 2015 Jan 28. doi: 10.1002/term.1987
2. Totani M, Ando T, Terada K, Terashima T, Kim I-Y, Ohtsuki C, Xi C, Kuroda K, Tanihara M; “Utilization of star-shaped polymer architecture in the creation of high-density polymer brush coatings for the prevention of platelet and bacteria adhesion,” Biomat Sci 2(9), 1172-1185, 2014
3. Kusumaatmaja A, Ando T, Terada K, Hirohara S, Nakashima T, Kawai T, Terashima T, Tanihara M, “Synthesis and photoproperties of Eu(III)-bearing star polymers as luminescent materials.” J Polym Sci Part A: Polym Chem 51(12), 2527-2535, 2013

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