NAIST Graduate School of Materials Science

Ade Arsianti of Synthetic Organic Chemistry laboratory received award as the first winner for oral presentation in the 2nd International Conference on Pharmacy and Advanced Pharmaceutical Science (ICPAPS) 2011.

Ade Arsianti of Synthetic Organic Chemistry laboratory received award as the first winner for oral presentation in the 2nd International Conference on Pharmacy and Advanced Pharmaceutical Science (ICPAPS) 2011. The conference was held on July 19-20, 2011 at Graha Sabha Pramana Gadjah Mada University, and was organized by Faculty of Pharmacy Gadjah Mada University in collaboration with Nara Institute of Science and Technology (NAIST) and Deutscher Akademischer Austausch Dienst-German Academic Exchange Service (DAAD). In this event, the participants came from 7 countries, 14 lectures in the field of Pharmaceutical care and Sciences were presented by the invited speakers, followed by presentation of 160 researchers in form of oral and poster presentation. The best oral and poster presentation have been awarded. This award is to recognize researchers’ contribution to the area of clinical and social pharmacy, pharmacy science and techonolgy, and advanced pharmaceutical science. A ceremony for the best oral presentation award in 2nd ICPAPS 2011 received by Ade Arsianti of Synthetic Organic Chemistry Laboratory, was held on July 20th 2011 at Graha Sabha Pramana, Gadjah Mada University, Yogyakarta, Indonesia

Synthesis and Anticancer Activity of Antimycin A3 Analogue

Ade Arsianti, Hiroki Tanimoto, Tsumoru Morimoto, Kiyomi Kakiuchi

I am so glad to receive this award. The data presented in this conference are my research data when I took Ph.D course in NAIST. I realized I could not get this award without supporting and collaboration from many other people. In this opportunity, I would like to express my greatest gratitude to Professor Kiyomi Kakiuchi, Associate Professor Tsumoru Morimoto, Dr. Hiroki Tanimoto and all members of Synthetic Organic Chemistry Laboratory for their help, valuable advices and great support. I express my deep appreciation to the President of NAIST, Professor Akira Isogai, and the Dean of Materials Science, NAIST, Professor Masao Tanihara for giving me grant-in-aid for scientific research during my study. I am deeply grateful to Professor Tatsuo Takeya and Dr. Anton Bahtiar of Graduate School of Biological Science, NAIST for the bioassay. I am also thankful Ms. Yoshiko Nishikawa for High Resolution Mass spectrometry measurement and Mr. Shouhei Katao for X-ray Crystallographic analysis.

Novel polyhydroxylated 18-membered analogue of antimycin A3 was synthesized. The synthesis was commenced with Boc-L-Threonine and was achieved by way of one-pot homocoupling of ring-closing metathesis reaction and Sharpless asymmetric dihydroxylation. The analogue exhibited a greater anticancer activity against HeLa cells, breast MDA-MB-231 cells, and prostate PC-3 cells than that of the original antimycin A3.

  • Prof. Dr. Marchaban (the Dean of Faculty of Pharmacy Gadjah Mada University) on her right side and Dr. Anton Bahtiar, the first winner for poster presentation who also graduated from graduate school of biological science NAIST on her left side
  • Appearance of ceremony

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