研究業績

 

原著論文


  1. 1.Kazuma Yasuhara, Manami Tsukamoto, Jun-ichi Kikuchi and Kenichi Kuroda
    An antimicrobial peptide-mimetic methacrylate random copolymer induces domain formation in a model bacterial membrane
    Journal of Membrane Biology, 2022, in press.


  1. 2.Toshinori Shimanouchi, Yasuhiro Sano, Kazuma Yasuhara, Yukitaka Kimura
    Amyloid-β aggregates induced by β-cholesteryl glucose-embedded liposomes
    Biochimica et Biophysica Acta (BBA) Proteins and Proteomics, 2022, in press.

  2. 3.Ryota Komatsu, Yasushi Tanimoto, Koji Ando, Kazuma Yasuhara, Yasuhiko Iwasaki, Fumio Hayashi and Kenichi Morigaki
    Nanofluidic Model Membrane for the Single-Molecule Observation of Membrane Proteins
    Langmuir, 2022, 38(23), 7234-7243.


  1. 4.Shixin Fa, Takuya Tomita,  Keisuke Wada,  Kazuma Yasuhara,  Shunsuke Ohtani, Kenichi Kato, Masayuki Gon,  Kazuo Tanaka, Takahiro Kakuta, Tada-aki Yamagishi and Tomoki Ogoshi
    CPL on/off control of an assembled system by water soluble macrocyclic chiral sources with planar chirality
    Chemical Science, 2022, 13, 5846-5853.


  1. 5.Ryuju Suzuki, Kazuma Yasuhara and Shigeru Deguchi
    Effect of Molecular Distortion on the Optical Properties of Carotenoid-Based Nanoparticles
    Journal of Physical Chemistry C, 2022, 126(5), 2607-2613.


  1. 6.Manami Tsukamoto, Emanuele Zappala, Gregory A. Caputo, Jun-ichi Kikuchi, Kayvan Najarian, Kenichi Kuroda and Kazuma Yasuhara
    Mechanistic Study of Membrane Disruption by Antimicrobial Methacrylate Random Copolymers by the Single Giant Vesicle Method
    Langmuir, 2021, 37(33) , 9982-9995.


  1. 7.Toshinori Shimanouchi, Tetsuya Hayashi, Kazuki Toramoto, Saki Fukuma, Keita Hayashi, Kazuma Yasuhara and Yukitaka Kimura
    Microfluidic and hydrothermal preparation of vesicles using sorbitan monolaurate/polyoxyethylene (20) sorbitan monolaurate (Span 20/Tween 20)
    Colloids and Surfaces B: Biointerfaces, 2021, 205, 11836.


  1. 8.Tamako Nishimura, Takuya Oyama, Hooi Ting Hu, Toshifumi Fujioka, Kyoko Hanawa-Suetsugu, Kazutaka Ikeda, Sohei Yamada, Hiroki Kawana, Daisuke Saigusa, Hiroki Ikeda, Rie Kurata, Kayoko Oono-Yakura, Manabu Kitamata, Kazuki Kida, Tomoya Hikita, Kiyohito Mizutani, Kazuma Yasuhara, Yuko Mimori-Kiyosue, Chitose Oneyama, Kazuki Kurimoto, Yoichiroh Hosokawa, Junken Aoki, Yoshimi Takai, Makoto Arita and Shiro Suetsugu
    Filopodium-derived vesicles produced by MIM enhance the migration of recipient cells
    Developmental Cell, 2021, 56(6), 842-859.e8.


  1. 9.Tomomi Koshiyama, Yuki Inoue, Sana Asada, Koki Kawahara, Shogo Ide, Kazuma Yasuhara and Masaaki Ohba
    pH-Dependent ion permeability control of a modified amphotericin B channel through metal complexation
    Chemical  Communications, 2021, 57, 2895-2898.


  1. 10.Aini Gusmira, Kazuhiro Takemura, Shin Yong Lee, Takehiko Inaba, Kyoko Hanawa-Suetsugu, Kayoko Oono-Yakura, Kazuma Yasuhara, Akio Kitao, and Shiro Suetsugu
    Regulation of caveolae through cholesterol-depletion dependent tubulation by PACSIN2/Syndapin II
    Journal of Cell Science, 2020, 133(19), jcs246785.


  1. 11.Toshio Nishino, Colin J. Martin, Hiroki Takeuchi, Florence Lim, Kazuma Yasuhara, Yohan Gisbert, Seifallah Abid, Nathalie Saffon‐Merceron, Claire Kammerer and Gwénaël Rapenne
    Dipolar Nanocars Based on a Porphyrin Backbone
    Chemistry - A European Journal,     2020, 26(52), 21010-12018.


  1. 12.Guolin Zhang, Li Zhang, Dan Zhang, Qiuhua Wu, Yoshihiro Sasaki, Yoshio Hisaeda, Kazuma Yasuhara, Jun-ichi Kikuchi and Xi-Ming Song
    Aerobic oxidation of thioglycol catalysed by metallophthalocyanine in an organic-inorganic hybrid vesicle “cerasome”
    Inorganic Chemistry Communications, 2020, 115, 107866.


  1. 13.Saki Fukuma, Toshinori Shimanouchi, Kazuma Yasuhara, Yukitaka KIMURA
    Analysis of the Partitioning Behavior of Horseradish Peroxidase to Phospholipid and Surfactant Membranes
    Solvent Extraction Research and Development, Japan, 2020, 27(2),113-123.


  1. 14.Atsushi Narumi, Tatsufumi Nakazawa, Kosuke Shinohara, Hiroki Kato, Yoshinori Iwaki, Haruya Okimoto, Moriya Kikuchi, Seigou Kawaguchi, Shodai Hino, Atsushi Ikeda, Montaser Shaykoon Ahmed Shaykoon, Xiande Shen, Qian Duan, Toyoji Kakuchi, Kazuma Yasuhara, Akihiro Nomoto, Yuji Mikata and Shigenobu Yano
    C60 Fullerene with Tetraethylene Glycols as a Well-defined Soluble Building Block and Saccharide-conjugation Producing PDT Photosensitizer
    Chemistry Letters, 2019, 48(10), 1209-1212.


  1. 15.Hongxu Yang, Masaru Yamanaka, Satoshi Nagao, Kazuma Yasuhara, Naoki Shibata, Yoshiki Higuchi and Shun Hirota
    Protein surface charge effect on 3D domain swapping in cells for c-type cytochromes
    Biochimica et Biophysica Acta (BBA) Proteins and Proteomics, 2019, 1867, 140265.


  1. 16.Partha Pratim Parui, Yeasmin Sarakar, Rini Majumder, Sanju Das, Hongxu Yang, Kazuma Yasuhara and Shun Hirota
    Determination of proton concentration at cardiolipin-containing membrane interfaces and its relation with the peroxidase activity of cytochrome c
    Chemical Science, 2019, 10, 9140-9151.


  1. 17.Bikash R. Sahoo, Takuya Genjo, Takahiro W. Nakayama, Andrea K. Stoddard, Toshio Ando, Kazuma Yasuhara, Carol A. Fierkead  and  Ayyalusamy Ramamoorthy
    A cationic polymethacrylate-copolymer acts as an agonist for β-amyloid and an antagonist for amylin fibrillation
    Chemical Science, 2019, 10, 3976-3986.


  1. 18.Yuya Goto, Masafumi Ueda, Kouta Sugikawa, Kazuma Yasuhara and Atsushi Ikeda
    Light-triggered Hydrophilic Drug Release from Liposomes through Removal of a Photoabile Protecting Group
    RSC Advances, 2019, 9, 166-171.


  1. 19.Haruko Takahashi, Kenji Yumoto, Kazuma Yasuhara, Enrico T. Nadres, Yutaka Kikuchi, Laura Buttitta, Russell S. Taichman and Kenichi Kuroda 
    Anticancer polymers designed for killing dormant prostate cancer cells
    Scientific Reports, 2018, 9(1), 10962019.


  1. 20.Bikash R. Sahoo, Takuya Genjo, Michael Bekier, Sarah J. Cox, Andrea K. Stoddard, Magdalena Ivanova, Kazuma Yasuhara, Carol A. Fierke, Yanzhuang Wang and  Ayyalusamy Ramamoorthy
    Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs
    Chemical Communications, 2018, 54(91)12883-128862018.


  1. 21.Yukari Oda, Kazuma Yasuhara, Shokyoku Kanaoka, Takahiro Sato, Sadahito Aoshima and Kenichi Kuroda
    Aggregation of Cationic Amphiphilic Block and Random Copoly(vinyl ether)s with Antimicrobial Activity
    Polymers, 2018, 10(1), 93.


  1. 22.Kazuma Yasuhara, Jin Arakida, Thirupathi Ravula, Sudheer Kumar Ramadugu, Bikash Sahoo, Jun-ichi Kikuchi and Ayyalusamy Ramamoorthy
    Spontaneous Lipid Nanodisc Fomation by Amphiphilic Polymethacrylate Copolymers
    Journal of the American Chemical Society, 2017, 139(51), 18657-18663.


  1. 23.Kouta Sugikawa, Tatsuya Kadota, Kotaro Matsuo, Kazuma Yasuhara and Atsushi Ikeda
    Growth of Anisotropic Gold Nanoparticle Assemblies by Fusion of Liposomes
    Materials, 2017, 10(11), 1317.


  1. 24.Kouta Sugikawa, Yutaro Takamatsu, Tomoyuki Kakigi, Kazuma Yasuhara, Atushi Ikeda
    Tubulation of Liposomes via the Interaction of Supramolecular Nanofibers
    Chemical Communications, 2017, 53, 7454-7456.


  1. 25.Chiaki Tsuneishi, Yuki Koizumi, Ryuta Sueto, Hiroki Nishiyama, Kazuma Yasuhara, Tada-aki Yamagishi, Tomoki Ogoshi, Ikuyoshi Tomita and Shinsuke Inagi
    Controlled synthesis of pillar[6]arene-based hexagonal cylindrical structures on an electrode surface by electrochemical oxidation
    Chemical Communications, 2017, 53, 7454-7456.


  1. 26.Kouta Sugikawa, Yutaro Takamatsu, Kazuma Yasuhara, Masafumi Ueda and Atsushi Ikeda
    Reversible Vesicle-to-Disk Transitions of Liposomes Induced by Self-Assembly of Water-Soluble Porphyrins
    Langmuir, 2017, 33(4), 1023-1029.


  1. 27.Yuta Matsuno, Asuka Onuma, Yoshie A Fujioka, Kazuma Yasuhara, Wataru Fujii, Kunihiko Naito and Koji Sugiura
    Effects of exosome-like vesicles on cumulus expansion in pigs in vitro
    Journal of Reproduction and Development, 2017, 63(1), 51-58.

  2. 28.Tomoki Ogoshi, Ryuta Sueto, Kumiko Yoshikoshi, Kazuma Yasuhara and Tada-aki Yamagishi
    Spherical Vesicles Formed by Co-Assembly of Cyclic Pentagonal Pillar[5]quinone with Cyclic Hexagonal Pillar[6]arene
    Journal of the American Chemical Society, 2016, 138 (26), 8064-8067.

  3. 29.Kouta Sugikawa, Tatsuya Kadota, Kazuma Yasuhara and Atsushi Ikeda
    Anisotropic Self-Assembly of Citrate-Coated Gold Nanoparticles on Fluidic Liposomes
    Angewandte Chemie International Edition, 2016, 55(12), 4059-4063.

  4. 30.Kazuma Yasuhara and Kenichi Kuroda
    Kinetic study of all-or-none hemolysis induced by cationic amphiphilic polymethacrylates with antimicrobial activity
    Chinese Chemical Letters, 2015, 26, 479-484.
    Featured as a Back Cover


  1. 31.Atsushi Ikeda, Shodai Hino, Tomoya Mae, Yuki Tsuchiya, Kouta Sugikawa,
    Manami Tsukamoto,     Kazuma Yasuhara, Hajime Shigeto, Hisakage Funabashi,
    Akio Kuroda and Motofusa Akiyama
    Porphyrin-uptake in liposomes and living cells using an exchange method with
    cyclodextrin
    RSC Advances, 2015, 5, 105279-105287.

  2. 32.Atsushi Ikeda, Shodai Hino, Kengo Ashizawa, Kouta Sugikawa, Jun-ichi Kikuchi, Manami Tsukamoto and Kazuma Yasuhara
    Lipid-membrane-incorporated hydrophobic photochromic molecules prepared by the exchange method using cyclodextrins
    Organic & Biomolecular Chemistry, 2015, 13, 6175-6182.

  3. 33.Manami Tsukamoto, Kenichi Kuroda, Ayyalusamy Ramamoorthy and Kazuma Yasuhara
    Modulation of raft domains in a lipid bilayer by boundary-active curcumin
    Chemical Communications, 2014, 50, 3427-3430.

  4. 34.Atsushi Ikeda, Kazuya Kiguchi, Tomohiro Hida, Kazuma Yasuhara, Kazuyuki Nobusawa, Motofusa Akiyama and Wataru Shinoda
    [70]Fullerenes Assists the Formation of Phospholipid Bicelles at Low Lipid Concentrations
    Langmuir, 2014, 30(41), 12315-12320.


  1. 35.Sendy Junedi, Kazuma Yasuhara, Satoshi Nagao, Jun-ichi Kikuchi, and Shun Hirota
    Morphological Change of Cell Membrane by Interaction with Domain-Swapped Cytochrome c Oligomers
    ChemBioChem, 2014, 15, 517-521.

  2. 36.Gemala Anjani, Akio Ohta, Kazuma Yasuhara and Tsuyoshi Asakawa
    Solubilization of genistein by caseinate micellar system
    Journal of Oleo Science, 2014, 63, 413-422.

  3. 37.Atsushi Ikeda, Tomohiro Hida, Tatsuya Iizuka, Manami Tsukamoto, Jun-ichi Kikuchi and Kazuma Yasuhara
    Dynamic behaviour in giant unilamellar vesicles induced by the uptake of [70]fullerene
    Chemical Communications, 2014, 50, 1228-1291.

  4. 38.Yoichi Sato, Kazuma Yasuhara, Jun-ichi Kikuchi and Thomas N. Sato
    Synthetic cell division system: Controlling equal vs. unequal divisions by design
    Scientific Reports, 2013, 3, 3475.

  5. 39.Kazuma Yasuhara, Takahiro Kawataki, Shizuyo Okuda, Shohei Oshima
    and Jun-ichi Kikuchi
    Spontaneously formed semipermeable organic–inorganic hybrid vesicles permitting molecular weight selective transmembrane passage
    Chemical Communications, 2013, 49, 665-667.
    Featured as an Inside Front Cover

  6. 40.Kazuma Yasuhara, Manami Tsukamoto, Yasutaka Tsuji and Jun-ichi Kikuchi
    Unique concentration dependence on the fusion of anionic liposomes induced
    by polyethyleneimine
    Colloids and Surfaces A: Physicochemical and Engineering Aspects,
    2012, 415, 461-467.

  7. 41.Kazuma Yasuhara, Hiroki Hayashi and Jun-ichi Kikuchi
    Thermal stability of synthetic lipid bicelles encompassed by siloxane surfaces as organic-inorganic hybrid nanodiscs
    Chemistry Letters, 2012, 41(10), 1223-1225.

  8. 42.Atsushi Ikeda, Miyuki Mori, Kazuya Kiguchi, Kazuma Yasuhara, Jun-ichi Kikuchi, Kazuyuki Nobusawa, Motofusa Akiyama, Mineo Hashizume, Takuya Ogawa, and Tatsuo Takeya
    Advantages and Potential of Lipid Membrane-Incorporating Fullerenes Prepared by the Exchange Reaction Method
    Chemistry an Asian Journal, 2012, 7(3), 605-613.

  9. 43.Takahiro Kawataki, Kazuma Yasuhara and Jun-ichi Kikuchi
    Remarkable Long-term Stability of Cerasome as an Organic-Inorganic Hybrid Nano-container for Water-soluble Macromolecules
    Chemistry Letters, 2011, 40(5), 461-463.


  1. 44.Kazuma Yasuhara, Shohei Miki, Hajime Nakazono, Akio Ohta and Jun-ichi Kikuchi
    Synthesis of Organic-Inorganic Hybrid Bicelles - Lipid Bilayer Nanodiscs Encompassed by Siloxane Surfaces
    Chemical Communications, 2011,47, 4691-4693.


  1. 45.Yoshihiro Sasaki, Masaru Mukai, Akihiro Kawasaki, Kazuma Yasuhara and Jun-ichi Kikuchi
    Switching of the Enzymatic Activity Synchronized with Signal Recognition by an Artificial DNA Receptor on a Liposomal Membrane
    Organic & Biomolecular Chemistry, 2011, 9, 2397-2402


  1. 46.Kazuma Yasuhara, Zhong-hua Wang, Takahiro Ishikawa, Jun-ichi Kikuchi, Yoshihiro Sasaki, Satoshi Hiyama, Yuki Moritani and Tatsuya Suda
    Specific delivery of transport vesicles mediated by complementary recognition of DNA signals with membrane-bound oligonucleotide lipids
    Supramolecular Chemistry, 2011, 23(3-4), 218-225.


  1. 47.Zhonghua Wang, Kazuma Yasuhara, Hiroshi Ito, Masaru Mukai and Jun-ichi Kikuchi
    Budding and Fission of Cationic Binary Lipid Vesicles Induced by the Incorporation of Pyranine
    Chemistry Letters, 2010, 39(1), 54-55.


  1. 48.Akio Ohta, Yuya Miyazato, Hiroyasu Sasaki, Kazuma Yasuhara and Tsuyoshi Asakawa
    Effect of Functional Groups on Incorporation Behavior of Amino Acid-Type Surfactant into Phospholipid Vesicle Membrane
    Journal of Oleo Science, 2009, 58, 607-615.


  1. 49.Kazuma Yasuhara, Yoshihiro Sasaki and Jun-ichi Kikuchi
    A photo-responsive cholesterol capable of inducing a morphological transformation of the liquid-ordered microdomain in lipid biayers
    Colloid and Polymer Science, 2008, 286, 1675-1680.


  1. 50.Kazuma Yasuhara, Yoshihiro Sasaki and Jun-ichi Kikuchi
    Fluorescent sensor responsive to local viscosity and its application to the imaging of liquid-ordered domain in lipid membranes
    Colloids and Surfaces B: Biointerfaces, 2008, 67, 145-149.


  1. 51.Noriko Yoshimoto, Makoto Yoshimoto, Kazuma Yasuhara, Toshinori Shimanouchi, Hiroshi Umakoshi and Ryoichi Kuboi
    Evaluation of temperature and guanidine hydrochloride-induced protein-liposome interactions by using immobilized liposome chromatography
    Biochemical Engineering Journal, 2006, 29, 174-18.


  1. 52.Kazuma Yasuhara, Toshinori Shimanouchi, Hiroshi Umakoshi and Ryoichi Kuboi
    Fluorescence study on the domain formation of N-dodecanoyl-l- tryptophan within a liposome membrane
    Colloid and Polymer Science, 2006, 285(2), 239-243.


  1. 53.Kazuma Yasuhara, Akio Ohta, Yoshihiro Asakura, Taishi Kodama, Tsuyoshi Asakawa and Shigeyoshi Miyagishi
    Unique incorporation behavior of amino acid-type surfactant into phospholipid vesicle membrane
    Colloid and Polymer Science, 2005, 283(9), 987-993.



解説記事・総説

  1. 1.安原 主馬
    生体膜に作用する機能性分子のバイオミメティック・デザイン
    材料表面, 2022, in press.


  1. 2.西野 智雄, 安原 主馬, ラッペン ゲナエル
    第2回国際ナノカーレース参戦記 -ナノメートルスケールのル・マン24時間耐久レース
    化学, 2022, in press.


  1. 3.鈴木 龍樹, 安原 主馬, 出口 茂
    完熟トマトはなぜあんなに赤い？〜カロテノイド微粒子中の歪んだ現実〜
    現代化学, 2022, 616, 37-39.


  1. 4.安原 主馬
    脂質膜のナノディスク化技術と熱測定への応用
    熱測定, 2021, 48(3), 108-113.


  1. 5.安原 主馬
    アミロイドタンパク質解析のための脂質ナノディスク
    膜(MEMBRANE), 2021, 46(1), 32-37.


  1. 6.Toshio Nishino, Colin J. Martin, Kazuma Yasuhara and Gwénaël Rapenne
    Molecular vehicles based on a polyaromatic or porphyrinic chassis
    Journal of Synthetic Organic Chemistry Japan, 2021, 79, 1050-1055.


  1. 7.Kazuma Yasuhara and Kenichi Morigaki
    New lipid membrane technologies for reconstitution, analysis, and utilization of 'living' membrane proteins
    Biophysics and Physicobiology, 2020, 17, 125-129.


  1. 8.安原 主馬
    細胞膜にはたらく両親媒性ポリマーのバイオミメティック・デザイン
    オレオサイエンス, 2020, 20(6), 275-282.


  1. 9.Claire Kammerer, Guillaume Erbland, Yohan Gisbert, Toshio Nishino, Kazuma Yasuhara and Gwénaël Rapenne Biomimetic and Technomimetic Single Molecular Machines
    Chemistry Letters, 2019, 48(4), 299-308.


  1. 10.安原 主馬
    支部発　話題欄　細胞膜機能を探る脂質ナノディスク　生きた膜タンパク質の解析をめざした新しいプラットフォーム
    化学と工業, 2019, 72(3), 240-241.


  1. 11.安原 主馬
    両親媒性ポリマーによる脂質ナノディスクの形成とアミロイドタンパク質解析への応用
    生体関連化学部会　ニュースレター, 2018,  33(3), 19-22.


  1. 12.Gwénaël Rapenne, 安原 主馬
    分子ホイールの合成から第１回ナノカーレースへの道のり
    高分子2018, 67(6), 317-320.


  1. 13.Cansu Ergene, Kazuma Yasuhara and Edmund. F. Palermo
    Biomimetic antimicrobial polymers: recent advances in molecular design
    Polymer Chemistry, 2018, in press (doi: 10.1039/c8py00012c).


  1. 14.安原 主馬
    脂質ナノディスクを自発形成する膜活性ポリマーのデザイン
    C&I Commun, 2018, 43(1), 29-31.


  1. 15.Haruko Takahashi, Edmund F. Palermo, Kazuma Yasuhara, Gregory A. Caputo and Kenichi Kuroda
    Molecular Design, Structures, and Activity of Antimicrobial Peptide-Mimetic Polymers
    Macromolecular Bioscience, 2013, 13(10), 1285–1299.
    Featured as a Back Cover


  1. 16.安原 主馬
    セラミック表面によって安定化された脂質二分子膜ナノディスクの形成
    C&I Commun, 2013, 38(1), 29-32.


  1. 17.安原 主馬
    注目の論文 脂質膜は名”翻訳”家?!
    化学, 2012, 67(7), 59-60.


  1. 18.安原主馬
    細菌の細胞膜に作用するポリマー抗菌剤の設計
    バイオマテリアルー生体材料, 2011, 29(4), 282-286.


  1. 19.安原 主馬, 菊池 純一
    自然のしくみに学ぶ次世代抗菌マテリアル　-細菌の細胞膜に働く抗菌ポリマーの設計-
    化学, 2009, 64(3), 72-73.


著書

  1. 1.Kazuma Yasuhara
    Synthetic mimics of membrane-active proteins and peptides
    Plasma Membrane Shaping, Elsevier, 2022, in press.


  1. 2.Kazuma Yasuhara, Kenichiro Omoto, Toshio Nishino and Gwénaël Rapenne
    Designed amphiphiles for cell membrane mimetic nanoarchitecture
    Concepts and design of materials nanoarchitectonics, Royal Society of Chemistry, 2022, 361-380.

  2. 3.Jun-ichi Kikuchi, Kazuma Yasuhara, Keishiro Tahara
    Integrated π-Electron Systems on Artificial Cell Membranes
    Chemical Science of π-Electron Systems, Springer, 2016, 457-474.

  3. 4.菊池 純一, 安原 主馬, 田原 圭志郞
    人工細胞膜の自己組織化能を利用する高次集積π空間の構築とナノデバイス機能
    高次π空間の創発と機能開発,シーエムシー出版, 2013, 140-145.

  4. 5.Jun-ichi Kikuchi and Kazuma Yasuhara
    Microscopy & Micro / Nano Imaging Techniques: TEM
    Supramolecular Chemistry: From Molecules to Nanomaterials, John & Wiley Sons,  2012, 633-646.


  1. 6.Jun-ichi Kikuchi and Kazuma Yasuhara
    Cerasome: Artificial Cell Membrane with Ceramic Surface
    Advances in Biomimetics, INTECH, 2010, 231-250.