1. Anion Effects on the Structure and Stability of 3D Domain-Swapped Cytochrome c Dimer
   Fujiwara, K.; Ryuzaki, M.; Yamanaka, M.; Mashima, T.; Saotome, T.; Kidokoro, S.-i.; Hirota, S. Chem. Lett. 2024, 53(8), upae150.
   
   
2. Construction of Ligand-Binding Controlled Hemoprotein Assemblies Utilizing 3D Domain Swapping
   Mashima, T.; Yamanaka, M.; Yoshida, A.; Kobayashi N.; Kanaoka, Y.; Uchihashi, T.; Hirota, S. J. Chem. Commun. 2024, 60, 9440-9443.
   
   
3. Why Is Dimeric 3D Domain Swapping in Antibody Light Chains Missing from the Solution? Atomistic Insights Mechanisms
   Duan, L.; Hengphasatporn, K.; Sakai, T.; Fujiki, R.; Yoshida, N.; Hirota, S.; Shigeta, Y. J. Phys. Chem. B 2024, 128(38), 9086–9093.
   
   
4. Experimental and Computational Studies on Domain-Swapped Structure Stabilization of an Antibody Light Chain by Disulfide Bond Introduction
   Fitriana, W.; Sakai, T.; Duan, L.; Hengphasatporn, K.; Shigeta, Y.; Mashimaa, T.; Uda, T.; Hifumi, E.; Hirota, S. J. Med. Chem.2024, 67(24), 22313-22321.
   
   
5. Synthesis and Reactivity of an Olefin Metathesis-Catalyzing Ruthenium Complex with a Selenoether Moiety in the Benzylidene Ligand
   Tsubasa Kinugawa, Seishu Mitsusada, Naoki Orito, Takashi Matsuo* ACS omega 2024, 9 (52), 51604–51610.
   
   
6. Structural and Electrochemical Properties of Mononuclear Copper(II) Complexes with Pentadentate Ethylenediamine-Based Ligands with Pyridine/Quinoline/Isoquinoline/Quinoxaline Binding Sites
   Yuji Mikata*, Miyu Akedo, Erina Hamamoto, Shoko Yoshida, Sunao Shoji, Yutaka Ohsedo, Takashi Matsuo, Tim Storr, Yasuhiro Funahashi Dalton Trans. 2024, 53 (40), 16716-16732.
   
   
7. A Bioinspired Bifunctional Catalyst: An Amphiphilic Organometallic Catalyst for Ring-Closing Metathesis Forming Liquid Droplets in Aqueous Media
   Miki Mori, Hiroka Sugai, Kohei Sato, Asuki Okada, Takashi Matsuo, Kazushi Kinbara* Chem. Commun. 2024, 60 (62), 7979–7982..
   
   
8. Cd2+-Specific Fluorescence Response of Methoxy-substituted N, N‑Bis(2-quinolylmethyl)-2-methoxyaniline Derivatives
   Yuji Mikata*, Nao Tosaka, Saori Yasuda, Yui Sakurai, Sunao Shoji, Hideo Konno, Takashi Matsuo Inorg. Chem. 2024, 63 (18), 8026–8037.
   
   
9. Cd2+-Selective Fluorescence Enhancement of N, N'’-Bis(2-quinolylmethyl)-N,N’'-dimethyl-1,2-phenylenediamine Derivatives
   Yuji Mikata*, Kaho Kawakami, Miho Nagaoka, Sunao Shoji, Hideo Konno, Takashi Matsuo Inorg. Chim. Acta. 2024, 565, 121968(1)–121968(11)
   
   
   

著書・解説

1. 3Dドメインスワッピングによる抗体軽鎖会合体の立体構造を原子レベルで特定
   廣田俊, 酒井隆裕, ISOTOPE NEWS 2024年10月号（利用技術）, 日本アイソトープ協会, 2024, 795, 10-13.
   
   

1. Effect of methoxy substituents on fluorescent Zn2+/Cd2+ selectivity of bisquinoline derivatives with a N,N'-dimethylalkanediamine skeleton
   Mikata, Y.; Tanaka, M.; Yasuda, S.; Tsuruta, A.; Hagiwara, T.; Konno, H.; Matsuo, T. Daltron Trans. 2023, 52(22), 11375-11388.
   
   
2. Resonance Raman Studies on Heme Ligand Stretching Modes of Methionine80-Depleted Cytochrome c: Fe-His, Fe-O2, and O-O Stretching Modes
   Zhang, M.; Tai, H.; Yanagisawa, S.; Yamanaka, M.; Ogura, T.; Hirota, S. J. Phys. Chem. B 2023, 127 (11), 2442-2449.
   
   
3. Conformation state-specific monobodies regulate the functions of flexible proteins through conformation trapping
   Nakamura, I.; Amesaka, H.; Hara, M.; Yonezawa, K.; Okamoto, K.; Kamikubo, H.; Tanaka, S.-I.; Matsuo, T. Protein Sci. 2023, 32 (12), e4813(1)-e4813(16).
   
   
4. Structural and thermodynamic insights into antibody light chain tetramer formation through 3D domain swapping.
   Sakai, T.; Mashima, T.; Kobayashi, N.; Ogata, H.; Duan, L.; Fujiki, R.; Hengphasatporn, K.; Uda, T.; Shigeta, Y.; Hifumi, E.; Hirota, S. Nat. Commun. 2023, 14, 7807(1)-7807(12).
   
   
5. Reactivity regulation for olefin metathesis-catalyzing ruthenium complexes with sulfur atoms at the terminal of 2-alkoxybenzylidene ligands.
   Kinugawa, T.; Matsuo, T. Dalton Trans. 2023, 52 (27), 9499-9508.
   
   
   

1. Structural and Spectroscopic Characterization of CO Inhibition of [NiFe]-Hydrogenase from Citrobacter sp. S-77
   Imanishi, T.; Nishikawa, K.; Taketa, M.; Higuchi, K.; Tai, H.; Hirota, S.; Hojo, H.; Kawakami, T.; Hataguchi, K.; Matsumoto, K.; Ogata, H.; Higuchi, Y. Acta Crystal. F 2022, 78(2), 66-74.
   
   
   
2. Heme-Bound Tyrosine Vibrations in Hemoglobin M: Resonance Raman, Crystallography and DFT Calculation
   Nagatomo, S.; Shoji, M.; Terada, T.; Nakatani, K.; Shigeta, Y.; Hirota, S.; Yanagisawa, S.; Kubo, M.; Kitagawa, T.; Nagai M.; Ohki, M; Park, S.-Y.; Shibayama N. Biophys. J. 2022, 121(14), 2767-2780.
   
   
   
3. Structural Region Essential for Amyloid Fibril Formation in Cytochrome c Elucidated by Optical Trapping
   Hirota, S.; Chiu, C.-L.; Chang, C.-J.; Lo, P.-H.; Chen, T.; Yang, H.; Yamanaka, M.; Mashima, T.; Xie, C.; Masuhara, H.; Sugiyama, T. Chem. Commun. 2022, 58(92), 12839-12842.
   
   
   
4. Cd2+-selective fluorescence response of TQEN (N,N,N',N'-tetrakis(2-quinolylmethyl)ethylenediamine) derivatives bearing ether oxygen-binding site
   Mikata, Y.; Kaneda, M.; Yonemura, S.; Akedo, M.; Konno, H.; Matsuo, T. Daltron Trans. 2022, 51, 17170-17179.
   
   

総説

1. Second and Outer Coordination Sphere Effects in Nitrogenase, Hydrogenase, Formate Dehydrogenase, and CO Dehydrogenase
   Stripp, S. T.; Duffus, B.R.; Fourmond, V.; Léger, C.; Leimkühler, S.; Hirota, S.; Hu., Y.; Jasniewsk, A.; Ogata, H.; Ribbe, M. Chem. Rev. 2022, 122(14), 11900-11973.
   
   

著書・解説

1. タンパク質3Dドメインスワッピングの研究 素晴らしい共同研究者と新しい環境から生まれた研究
   廣田俊, 化学と工業, 私の自慢, 日本化学会, 2022, 75(4), 283-285.
   
   

1. Rational Design of Metal-Binding Sites in Domain-Swapped Myoglobin Dimers
   Nagao, S.; Idomoto, A.; Shibata, N.; Higuchi, Y.; Hirota, S. J. Inorg. Biochem. 2021, 217, 111374.
   
   
2. Construction of Ferritin Hydrogels Utilizing Subunit–Subunit Interactions
   Yamanaka, M.; Mashima, T.; Ogihara, M.; Okamoto, M.; Uchihashi, T.; Hirota, S. PLoS One 2021, 16(11), e0259052.
   
   
3. Experimental and Theoretical Study on Converting Myoglobin into a Stable Domain-Swapped Dimer by Utilizing a Tight Hydrogen Bond Network at the Hinge Region
   Xie, C.; Shimoyama, H.; Yamanaka, M.; Nagao, S.; Komori, H.; Shibata, N.; Higuchi, Y.; Shigeta, Y.; Hirota, S. RSC Advances 2021, 11(5), 37604-37611.
   
   

総説

1. New Aspects of Cytochrome c: 3D Domain Swapping, Membrane Interaction, Peroxidase Activity, and Met80 Sulfoxide Oxidation
   Hirota, S.; Nagao, S. Bull. Chem. Soc. Jpn. (Award Account) 2021, 94(1), 170-182 (Featured on Inside Cover).
   
   
2. Proton Transfer Mechanisms in Bimetallic Hydrogenases
   Tai, H.; Hirota, S.; Stripp, S. Acc. Chem. Res. 2021, 54(1), 232-241.
   
   
3. Functionalization of Ruthenium Olefin-metathesis Catalysts for Interdisciplinary Studies in Chemistry and Biology
   Matsuo, T. Catalysts 2021, 11(3), 359(1)-359(25) (special issue on "Converging Chemistry and Biology: Chemoenzymatic Cascade Reactions and Biohybrid Catalysts").
   
   
4. 生体分子への適用を指向したHoveyda-Grubbs型錯体の機能化
   松尾 貴史有機合成化学 2021, 79(4), 311-321 (総合論文).
   
   
5. Use of 3D Domain Swapping in Constructing Supramolecular Metalloproteins
   Hirota, S.; Mashima, T.; Kobayashi, N. Chem. Commun. (Future Article) 2021, 57(91), 12074-12086.
   
   

1. Regioselective Chemical Modification of Cysteine Residues on Protein Surfaces Focusing on Local Environment around the Conjugation Site
   Miyake, T.; Tamaki, R.; Asanuma, M.; Fukada, Y.; Hirota, S.; Matsuo, T. Bioconjugate Chem. 2020, 31(3), 794-802.
   
   
2. 3D Domain Swapping of Azurin from Alcaligenes xylosoxidans
   Cahyono, R. N.; Yamanaka, M.; Nagao, S.; Shibata, N.; Higuchi, Y.; Hirota, S. Metallomics 2020, 12(3), 337-345. (Featured on “Front Cover”)
   
   
3. Thermodynamic Control of Domain Swapping by Modulating Helical Propensity in the Hinge Region of Myoglobin
   Nagao, S.; Suda, A.; Kobayashi, H.; Shibata, N.; Higuchi, Y.; Hirota, S. Chem. Asian J. 2020, 15(11), 1743-1749. (Selected as “Very Important Paper”)
   
   
4. Second-Coordination Sphere Effects on the Reactivities of Hoveyda–Grubbs-Type Catalysts: A Ligand Exchange Study Using Phenolic Moiety-Functionalized Ligands
   Jatmika, C.; Goshima, K.; Wakabayashi, K.; Akiyama, N.; Hirota, S.; Matsuo, T. Dalton Trans. 2020, 49(33), 11618-11627.
   
   
5. Ligand Exchange Strategy for Delivery of Ruthenium Complex Unit to Biomolecules Based on Ruthenium-Olefin Interactions
   Jatmika, C.; Wakabayashi, K.; Tamaki, R.; Nakamura, I.; Akiyama, N.; Hirota, S.; Yamaguchi, H.; Matsuo, T. Chem. Lett. 2020, 49(12), 1490-1493.
   
   

総説

1. Mechanism and Application of the Catalytic Reaction of [NiFe] Hydrogenase: Recent Developments
   Tai, H.; Hirota, S. ChemBioChem (Concept) 2020, 21(11), 1573-1581. (Selected as “Very Important Paper”)
   
   

著書・解説

1. 2020年の化学：最新のトピックス（ここまできた!!タンパク質設計―人工酵素、超分子創製からコンピュータデザインまで）
   廣田俊, 月刊化学 2月号, 化学同人, 2020, 75(3), 70-71.
   
   
2. Part II 研究最前線 第7章 タンパク質の超分子制御
   廣田俊, CSJカレントレビュー 36「生体分子反応を制御する：化学的手法による機構と反応場の解明」, 日本化学会編（民秋均, 深瀬浩一, 杉本直己）, 化学同人, 東京, 2020, pp 83-88.（カバーデザイン）
   
   
3. Part III 革新論文 No. 9, No. 36, No. 37
   廣田俊, CSJカレントレビュー 36「生体分子反応を制御する：化学的手法による機構と反応場の解明」, 日本化学会編（民秋均, 深瀬浩一, 杉本直己), 化学同人, 東京, 2020, p 172, p 179.
   
   
4. Part I 基礎概念と研究現場 第2章 Basic concept-4 生体反応場の特徴と金属錯体の性質の融合による触媒機能の創発
   松尾 貴史, CSJカレントレビュー 37 「高機能性金属錯体が拓く触媒科学：革新的分子変換反応の創出をめざして」, 日本化学会編（岩澤伸治, 宇都宮賢, 荘司長三, 鷹谷絢, 中尾佳亮）, 化学同人, 東京, 2020, pp 28-31
   
   

1. Conferment of CO-controlled Dimer–Monomer Transition Property to Thermostable Cytochrome c' by Mutation in the Subunit–Subunit Interface
   Yamanaka, M.; Nakayama, R.; Fujii, S.; Wakai, S.; Sambongi, Y.; Hirota, S. Bull. Chem. Soc. Jpn. 2019, 92(3), 702-709.
   
   
2. Construction of a Quadrangular Tetramer and a Cage-Like Hexamer from Three-Helix Bundle-Linked Fusion Proteins
   Miyamoto, T.; Hayashi, Y.; Yoshida, K.; Watanabe, H.; Uchihashi, T.; Yonezawa, K.; Shimizu, N.; Kamikubo, H.; Hirota, S. ACS Synth. Biol. 2019, 8(5), 1112-1120.
   
   
3. Domain-Swapping Design by Polyproline Rod Insertion
   Shiga, S.; Yamanaka, M.; Fujiwara, W.; Hirota, S.; Goda, S.; Makabe, K. ChemBioChem 2019, 20(19), 2454-2457.
   
   
4. Protein Surface Charge Effect on 3D Domain Swapping in Cells for c-type Cytochromes
   Yang, H.; Yamanaka, M.; Nagao, S.; Yasuhara, K.; Shibata, N.; Higuchi, Y.; Hirota, S. Biochim. Biophys. Acta-Proteins Proteom. 2019, 1867(11),140265
   
   
5. Cysteine SH and Glutamate COOH Contributions to [NiFe] Hydrogenase Proton Transfer Revealed by Highly Sensitive FTIR Spectroscopy
   Tai, H.; Nishikawa, K.; Higuchi, Y.; Mao, Z.-w.; Hirota, S. Angew. Chem. Int. Ed. 2019, 58(38),13285-13290.
   
   
6. Determination of Proton Concentration at Cardiolipin-Containing Membrane Interfaces and Its Relation with the Peroxidase Activity of Cytochrome c
   Parui, P. P.; Sarakar, Y.; Majumder, R.; Das, S.; Yang, H.; Yasuhara, K.; Hirota, S. Chem. Sci. 2019, 10(39), 9140-9051.
   
   

総説

1. Oligomerization of Cytochrome c, Myoglobin, and Related Heme Proteins by 3D Domain Swapping
   Hirota, S. J. Inorg. Biochem. 2019, 194, 170-179.
   
   
2. Recent Developments on Creation of Artificial Metalloenzymes
   Matsuo, T.; Miyake, T.; Hirota, S. Tetrahedron Lett. 2019, 60, 151226 (8 pages).
   
   

1. ゲル組成物及びゲル乾燥物
   発明者：廣田俊, 山中優, 荻原理生, 出願番号：特願2019-096891 (2019.5.23), 出願人：奈良先端科学技術大学院大学.

1. Theoretical Analysis of the Domain-Swapped Dimerization of Cytochrome c: An MD and 3D-RISM Approach
   Yoshida, N.; Higashi, M.; H. Motoki H.; Hirota, S. J. Chem. Phys. 2018, 148(2), 025102 (7 pages).
   
   
2. Global Structural Flexibility of Metalloproteins Regulates Reactivity of Transition Metal Ion in the Protein Core: An Experimental Study Using Thiol-subtilisin as a Model Protein
   Matsuo, T.; Kono, T.; Shobu, I.; Ishida, M.; Gonda, K.; Hirota, S. Eur. J. Chem. 2018, 24(11), 2767-2775.
   
   
3. Oxidative Modification of Methionine80 in Cytochrome c by Reaction with Peroxides
   Nugraheni, A. D.; Ren, C.; Matsumoto, Y.; Nagao, S.; Yamanaka, M.; Hirota, S. J. Inorg. Biochem. 2018, 182, 200-207.
   
   
4. Construction of a Triangle-Shaped Trimer and a Tetrahedron Using an α-Helix-Inserted Circular Permutant of Cytochrome c₅₅₅
   Oda, A.; Nagao, S.; Yamanaka, M.; Ueda, I.; Watanabe, H.; Uchihashi, T.; Shibata, N.; Higuchi, Y.; Hirota, S. Chem. Asian J. 2018, 13(8), 964-967. Featured on “Front Cover”.
   
   
5. シトクロムcの多量体形成に関する理論的研究
   根木秀佳, 吉田紀生, 廣田俊, 東雅大, J. Comput. Chem. Jpn., 日本コンピュータ化学会, Account (総合論文), 2018, 17(1), 8-13.
   
   
6. Redox-dependent Conformational Changes of a Proximal [4Fe–4S] Cluster in Hyb-type [NiFe]-hydrogenase to Protect the Active Site from O₂
   Noor, N. D. M.; Matsuura, H.; Nishikawa, K.; Tai, H.; Hirota, S.; Kim, J.; Kang, J.; Tateno, M.; Yoon, K.-S.; Ogo, S.; Kubota, S.; Shomura, Y.; Higuchi, Y. Chem. Commun. 2018, 54(87), 12385-12388.
   
   
7. Synergistic Effect of Distal Polar Interactions in Myoglobin and Their Structural Consequences
   Watanabe, M.; Kanai, Y.; Nakamura, S.; Nishimura, R.; Shibata, T.; Momotake, A.; Yanagisawa, S.; Ogura, T.; Matsuo, T.; Hirota, S.; Neya, S.; Suzuki, A.; Yamamoto Y. Inorg. Chem. 2018, 57(22), 14269-14279.
   
   

総説

1. Design of Artificial Metalloproteins/Metalloenzymes by Tuning Noncovalent Interactions
   Hirota, S.; Lin, Y.-W. J. Biol. Inorg. Chem. 2018, 23(1), 7-25.
   
   
2. Comprehensive Reaction Mechanisms at and nearby the Ni‒Fe Active Sites of [NiFe] Hydrogenases
   Tai, H.; Higuchi, Y.; Hirota, S. Dalton Trans. (Perspective) 2018, 47(13), 4408-4423.
   

著書・解説

1. 薬学教科書シリーズ 3 物理化学
   石田寿昌, 斎藤博幸, 佐野洋, 友尾幸司, 根矢三郎, 廣田俊共著, 石田寿昌編, 第2版, 化学同人, 京都, 2018, 6章自由エネルギーと化学ポテンシャル, 7章化学平衡, 8章相平衡, pp 75-116.
   
   
2. 大学とグローバル化（巻頭言）
   廣田俊, 日本化学会生体機能関連化学部会ニュースレター, 日本化学会生体機能関連化学部会, 2018, 32(4), 2-3.
   
   

1. Formation and Carbon Monoxide-Dependent Dissociation of Allochromatium vinosum Cytochrome c’ Oligomers Using Domain-Swapped Dimers
   Yamanaka, M.; Hoshizumi, M.; Nagao, S.; Nakayama, R.; Shibata, N.; Higuchi, Y.; Hirota, S. Protein Sci. 2017, 26(3), 464-474.
   
   
2. Improved Stopped-Flow Time-Resolved Resonance Raman Spectroscopy Device for Studying Enzymatic Reactions
   Yanagisawa, S. Deshpande, M. S.; Hirota, S.; Nakagawa, T.; Ogura, T. J. Raman Spectrosc. 2017, 48(5), 680-685.
   
   
3. Effect of Methionine80 Heme Coordination on Domain Swapping of Cytochrome c
   Hirota, S.; Yamashiro, N.; Wang, Z.; Nagao, S. J. Biol. Inorg. Chem. 2017, 22(5), 705-712.
   
   
4. A Single Spherical Assembly of Protein Amyloid Fibrils Formed by Laser Trapping
   Yuyama, K.; Ueda, M.; Nagao, S.; Hirota, S.; Sugiyama, T.; Masuhara, H. Angew. Chem. Int. Ed. 2017, 56(24), 6739-6743. Selected as "Hot Paper".
   
   
5. Structural Basis of the Redox Switches in the NAD+-Reducing Soluble [NiFe]-Hydrogenase
   Shomura, Y.; Taketa, M.; Nakashima, H.; Tai, H.; Nakagawa, H.; Ikeda, Y.; Ishii, M.; Igarashi, Y.; Nishihara, H.; Yoon, K.-S.; Ogo, S.; Hirota, S.; Higuchi, Y. Science 2017, 357(6354), 928-932.
   
   
6. Rational Design of Domain-Swapping-Based c-Type Cytochrome Heterodimers by Using Chimeric Proteins
   Zhang, M.; Nakanishi, T.; Yamanaka, M.; Nagao, S.; Yanagisawa, S.; Shomura, Y.; Shibata, N.; Ogura, T.; Higuchi, Y.; Hirota, S. ChemBioChem 2017, 18(17), 1712-1715.
   
   
7. Equilibrium between Inactive Ready Ni-SIr and Active Ni-SIa States of [NiFe] Hydrogenase Studied by Utilizing Ni-SIr-to-Ni-SIa Photoactivation
   Tai, H.; Xu, L.; Nishikawa, K.; Higuchi, Y.; Hirota, S. Chem. Commun 2017, 53(75), 10444-10447.
   
   
8. Activation Mechanism of Streptomyces Tyrosinase Assisted by the Caddie Protein
   Matoba, Y.; Kihara, S.; Muraki, Y.; Bando, N.; Yoshitsu, H.; Kuroda, T.; Sakaguchi, M.; Kayama, K.; Tai, H.; Hirota, S.; Ogura, T.; Sugiyama, M. Biochemistry 2017, 56(41), 5593-5603.
   
   
9. Hydrophobicity of Residue 128 of the Stress-Inducible Sigma Factor RpoS Is Critical for Its Activity
   Iwase, T.; Matsuo, T.; Nishioka, S.; Tajima, A.; Mizunoe, Y. Front Microbiol 2017, 8, 656.
   

著書・解説

1. Fe, Co, Ru, Rh
   廣田俊, 元素118の新知識, ブルーバッククス, 桜井弘編, 講談社, 東京, 2017, pp 152-158; 159-164; 231-232; 233-235.
   
   
2. タンパク質ドメインスワッピングの構造・機構解析
   廣田俊, 長尾聡, 山中優, ぶんせき2017年10月号, 日本分析化学会, 2017, 464-467.
   

1. Domain swapping oligomerization of thermostable c-type cytochrome in E. coli cells
   Hayashi, Y.; Yamanaka, M.; Nagao, S.; Komori, H.; Higuchi, Y.; Hirota, S. Sci. Rep. 2016, 6, 19334 (8 pages).
   
   
2. Effect of Heme Electronic Structure and Distal Polar Interaction on Functional and Vibrational Properties of Myoglobin
   Kanai, Y.; Nishimura, R.; Nishiyama, K.; Shibata, T. Yanagisawa, S.; Ogura, T.; Matsuo, T.; Hirota, S.; Neya, S.; Suzuki, A.; Yamamoto, Y. Inorg. Chem. 2016, 55, 1613-1622.
   
   
3. A Simple Interfacial pH Detection Method for Cationic Amphiphilic Self-assemblies Utilizing a Schiff-base Molecule
   Sarkar, Y. ; Das, S.; Ray, A.; Jewrajka, S. K.; Hirota, S.; Parui, P. P. Analyst 2016, 141, 2030-2039.
   
   
4. Photoactivation of the Ni-SIr State to the Ni-SIa State in [NiFe] Hydrogenase: FT-IR Study on the Light Reactivity of the Ready Ni-SIr State and As-isolated Enzyme Revisited
   Tai, H.; Xu, L.; Nishikawa, K.; Inoue, S.; Higuchi, Y.; Hirota, S. Phys. Chem. Chem. Phys. 2016, 18, 22025 - 22030.
   
   
5. Characterization of Cytochrome c Membrane-Binding Site Using Cardiolipin-Containing Bicelles with NMR
   Kobayashi, H.; Nagao, S.; Hirota, S. Angew. Chem. Int. Ed. 2016, 55, 14019-14022.
   

著書・解説

1. 第2章 O2の運搬・貯蔵・活性化, 2-1運搬・貯蔵
   廣田俊, 錯体化学会フロンティア選書「フロンティア生物無機化学」,伊東忍, 青野重利, 林高史編著, 三共出版, 東京, 2016, pp 34-51.
   
   
2. ヒドロゲナーゼによる水素分解・合成機構および酵素燃料電池への応用
   廣田俊, 加納健司, 樋口芳樹, 月刊「BIO INDUSTRY」1月号, シーエムシー出版, 2016, 33, 43-48.
   
   
3. ドメインスワッピング機構によるタンパク質超分子化
   山中優, 廣田俊, 化学と生物 5月号, 日本農芸化学会, 2016, 54, 315-317.
   

1. Rational Design of Heterodimeric Protein Using Domain Swapping for Myoglobin
   Lin, Y.-W.; Nagao, S.; Zhang, M.; Shomura, Y.; Higuchi, Y.; Hirota, S. Angew. Chem. Int. Ed. 2015, 54, 511-515.
   
   
2. Change in Structure and Ligand Binding Properties of Hyperstable Cytochrome c₅₅₅ from Aquifex aeolicus by Domain Swapping
   Yamanaka, M.; Nagao, S.; Komori, H.; Higuchi, Y.; Hirota, S. Protein Sci. 2015, 24, 366-375.
   
   
3. Carbon Monoxide Binding Properties of Domain-Swapped Dimeric Myoglobin Nagao, S.; Ishikawa, H.; Yamada, T.; Mizutani, Y.; Hirota, S. J. Biol. Inorg. Chem. 2015, 20, 253-530.
   
   
4. Dimer Domain Swapping versus Monomer Folding in Apo-myoglobin Studied by Molecular Simulations
   Ono, K.; Ito, M.; Hirota, S.; Takada, S. Phys. Chem. Chem. Phys. 2015, 17, 5006-5013.
   
   
5. Excimer Emission Properties on Pyrene-labeled Protein Surface: Correlation between Emission Spectra, Ring Stacking Modes and Flexibilities of Pyrene Probes
   Fujii, A.; Sekiguchi, Y.; Matsumura, H.; Inoue, T.; Chung, WS.; Hirota, S.; Matsuo, T. Bioconjugate Chem. 2015, 26, 537-48.
   
   
6. Domain-Swapped Dimer of Pseudomonas aeruginosa Cytochrome c₅₅₁: Structural Insights into Domain Swapping of Cytochrome c Family Proteins
   Nagao, S.; Ueda, M.; Osuka, H.; Komori, H.; Kamikubo, H.; Kataoka, M.; Higuchi, Y.; Hirota, S. PLoS One 2015, 10, e0123653.
   
   
7. Effect of a Procaspase-Activating Compound on the Catalytic Activity of Mature Caspase-3
   Matsuo, T.; Yamada, K.; Ishida, M.; Miura, Y.; Yamanaka, M.; Hirota, S. Bull. Chem. Soc. Jap. 88, 2015, 1221-1229. BCSJ award
   
   
8. Domain-swapped Cytochrome cb₅₆₂ Dimer and Its Nanocage Encapsulating a Zn–SO₄ Cluster in the Internal Cavity
   Miyamoto, T.; Kuribayashi, M.; Nagao, S.; Shomura, Y.; Higuchi, Y.; Hirota, S. Chem. Sci. 2015, 6, 7336-7342.
   
   
9. Oligomerization Enhancement and Two Domain Swapping Mode Detection for Thermostable Cytochrome c₅₅₂ via the Elongation of the Major Hinge Loop
   Ren, C.; Nagao, S.; Yamanaka, M.; Komori, H.; Shomura, Y.; Higuchi, Y., Hirota, S. Mol. Biosyst. 2015, 11, 3218-3221.
   
   
10. FT-IR Characterization of the Light-Induced Ni-L2 and Ni-L3 States of [NiFe] Hydrogenase from Desulfovibrio vulgaris Miyazaki F
    Tai, H.; Nishikawa, K.; Inoue, S.; Higuchi, Y.; Hirota, S. J. Phys. Chem. B 2015, 119, 13668-13674.
    
    

解説

1. シトクロムcの モルテングロビュール状態と会合体形成
   廣田俊, 生物物理（トピックス）, 日本生物物理学会, 2015, 55, 87-88.

1. Self-Assembled Dimerization of Bis(crown ether)-2,2’-bibenzimidazoles
   Satake, A.; Tanaka, K.; Asakura, H.; Okano, M.; Hashimoto, T,; Matsuura, Y.; Inaba, Y.; Oda, T.; Hirota, S.; Koshino, H. Bull. Chem. Soc. Jpn. 2014, 87, 88-97.
   
   
2. Electronic Control of Discrimination between O₂ and CO in Myoglobin the Lacking Distal Histidine Residue
   Nishimura, R.; Shibata, T.; Ishigami, I.; Ogura, T.; Tai, H.; Nagao, S.; Matsuo, T.; Hirota, S.; Shoji, O.; Watanabe, Y.; Imai, K.; Neya, S.; Suzuki, A.; Yamamoto, Y. Inorg. Chem. 2014, 53, 1091–1099.
   
   
3. H₂O₂-dependent Substrate Oxidation by an Engineered Diiron Site in a Bacterial Hemerythrin
   Okamoto, Y.; Onoda, A.; Sugimoto, H.; Takano, Y.; Hirota, S.; Kurtz, Jr., D. M.; Shiro, Y.; Hayashi T., Chem. Commun. 2014, 50, 3421-3423.
   
   
4. Morphological Change of Cell Membrane by Interaction with Domain-Swapped Cytochrome c Oligomers
   Junedi, S.; Yasuhara, K.; Nagao, S.; Kikuchi, J., Hirota, S. ChemBioChem 2014, 15, 517-521.
   
   
5. Formation of Domain-Swapped Oligomer of Cytochrome c from Its Molten Globule State Oligomer
   Deshpande, M. S.; Parui, P. P.; Kamikubo, H.; Yamanaka, M.; Nagao, S.; Komori, H.; Kataoka, M.; Higuchi, Y.; Hirota, S. Biochemistry 2014, 53, 4696-4703.
   
   
6. Electronic Control of Ligand-Binding Preference of a Myoglobin Mutant
   Nishimura, R.; Matsumoto, D.; Shibata, T.; Yanagisawa, S.; Ogura, T.; Tai, H.; Matsuo, T.; Hirota, S.; Neya, S.; Suzuki, A.; Yamamoto, Y. Inorg. Chem. 2014, 53, 9156-9165.
   
   
7. Self-Oxidation of Cytochrome c at Methionine80 with Molecular Oxygen Induced by Cleavage of the Met−Heme Iron Bond
   Wang, Z.; Ando, Y.; Nugraheni, A. D.; Ren, C.; Nagao, S.; Hirota, S. Mol. BioSyst. 2014, 10, 3130-3137.
   
   
8. DNA Cleavage by Oxymyoglobin and Cysteine-Introduced Metmyoglobin
   Deshpande, M. S.; Junedi, S.; Prakash, H.; Nagao, S.; Yamanaka, M.; Hirota, S.Chem. Commun. 2014, 50, 15034-15036.
   
   
9. Control of the Transition between Ni-C and Ni-SIa States by the Redox State of the Proximal Fe-S Cluster in the Catalytic Cycle of [NiFe] Hydrogenase
   Tai, H.; Nishikawa, K.; Suzuki, M.; Higuchi, Y.; Hirota, S., Angew. Chem. Int. Ed. 2014, 53, 13817-13820.
   
   
10. Structural characterization of imidazole adducts of heme-DNA complexes
    Suzuki, Y.; Tai, H.; Saito, K.; Shibata, T.; Kinoshita, M.; Suzuki, A.; Yamamoto, Y., J. Porphyrins Phthalocyanines 2014, 18, 741-751.
    
    
11. Effect of the electron density of the heme Fe atom on the Fe-histidine coordination bond in deoxy myoglobin
    Nishimura, R.; Shibata, T.; Tai, H.; Ishigami, I.; Yanagisawa, S.; Ogura, T.; Neya, S.; Suzuki, A.; Yamamoto, Y., Bull. Chem. Soc. Jpn. 2014, 87, 905-911.
    
    

総説

1. Artificial Enzymes with Protein Scaffolds: Structural Design and Modification
   Matsuo, T.; Hirota, S. Bioorg. Med. Chem. 2014, 22, 5638-5656.
   

解説

1. タンパク質超分子をパズルのように創る――組織化された次世代超分子の創成を目指して
   廣田俊, 長尾聡, 月刊化学5月号, 化学同人, 2014, 69, 45-49.
   
   
2. ミクロの世界の工作
   廣田俊, 読売新聞奈良版（ドキ★ワク先端科学 第16回）, 2014, 12月16日, 朝刊, p30.
   

1. Photosensitivity of the Ni-A state of [NiFe] hydrogenase from Desulfovibrio vulgaris Miyazaki F with visible light
   Osuka, H.; Shomura, Y.; Komori, H.; Shibata, N.; Nagao, S.; Higuchi, Y.; Hirota, S. Biochem. Biophys. Res. Commun. 2013, 430, 284-288.
   
   
2. Interaction of dimeric horse cytochrome c with cyanide ion
   Nugraheni, A.D.; Nagao, S.; Yanagisawa, S.; Ogura, T.; Hirota, S. J. Biol. Inorg. Chem. 2013, 18, 383-390.
   
   
3. Relationship between the electron density of the heme Fe atom and the vibrational frequencies of the Fe-bound carbon monoxide in myoglobin
   Nishimura, R.; Shibata, T.; Tai, H.; Ishigami, I.; Ogura, T.; Nagao, S.; Matsuo, T.; Hirota, S.; Imai, K.; Neya, S.; Suzuki, A.; Yamamoto, Y.; Inorg. Chem. 2013, 52, 3349-3355.
   
   
4. Reversible switching of fluorophore property based on intrinsic conformational transition of adenylate kinase during its catalytic cycle
   Fujii, A.; Hirota, S.; Matsuo, T. Bioconjug. Chem. 2013, 24, 1218-1225.
   
   
5. Effect of Added Salt on Ring-closing Metathesis Catalyzed by a Water-soluble Hoveyda-Grubbs Type Complex to Form N-Containing Heterocycles in Aqueous Media
   Matsuo, T.; Yoshida, T.; Fujii, A.; Kawahara, K.; Hirota, S. Organometallics 2013, 32, 5313-5319.
   
   　　　　　　　
6. Crystal Structure, Exogenous Ligand Binding and Redox Properties of an Engineered Diiron Active Site in a Bacterial Hemerythrin
   Okamoto, Y.; Onoda, A.; Sugimoto, H.; Takano, Y.; Hirota, S.; Kurtz, Jr., D. M.; Shiro, Y,; Hayashi, T. Inorg. Chem. 2013, 52, 13014-13020.
   　　　　　　　
   
7. Formation of Oligomeric Cytochrome c during Folding by Intermolecular Hydrophobic Interaction between N- and C-Terminal α-Helices
   Parui, P. P.; Deshpande, M. S.; Nagao, S.; Kamikubo, H.; Komori, H.; Higuchi, Y.; Kataoka, M.; Hirota, S. Biochemistry 2013, 52, 8732-8744.
   
   
8. NMR Spectroscopic Study of the Complexation Behaviors of Deuterated Cyclodextrins and [60]Fullerene
   Ikeda, A.; Hida, T.; Kikuchi, J.; Nobusawa, K.; Matsuo, T.; Org. Lett. 2013, 15, 6194-6197.
   

1. 可逆的に相転移する温度応答性タンパク質およびその製造法
   発明者：廣田俊, 山中優, 具志堅利実子, 出願番号：特願2013-197018

1. Creation of an Artificial Metalloprotein with a Hoveyda-Grubbs Catalyst Moiety through the Intrinsic Inhibition Mechanism of α-Chymotrypsin
   Matsuo, T.; Imai, C.; Yoshida, T.; Saito, T.; Hayashi, T. Hirota, S. Chem. Commun. 2012, 48, 1662-1664.
   
   
2. Structural and Oxygen Binding Properties of Dimeric Horse Myoglobin
   Nagao, S.; Osuka, H.; Yamada, T.; Uni, T.; Shomura, Y.; Higuchi, Y.; Hirota, S. Dalton Trans. 2012, 41, 11378-11385.
   
   
3. Domain Swapping of the Heme and N-terminal α-helix in Hydrogenobacter thermophilus Cytochrome c₅₅₂ Dimer
   Hayashi, Y.; Nagao, S.; Osuka, H.; Komori, H.; Higuchi, Y.; Hirota, S. Biochemistry 2012, 51, 8608-8616.
   
   
4. Relationship between Oxygen Affinity and Autoxidation of Myoglobin
   Shibata, T.; Matsumoto, D.; Nishimura, R.; Tai, H.; Matsuoka, A.; Nagao, S.; Matsuo, T.; Hirota, S.; Imai, K.; Neya, S.; Suzuki, A.; Yamamoto, Y. Inorg. Chem. 2012, 51, 11955-11960.
   
   
5. Efficient Oxidative Cycloreversion Reaction of Photochromic Dithiazolythiazole
   Nakashima, T.; Kajiki, Y.; Fukumoto, S.; Taguchi, M.; Nagao, S.; Hirota, S.; Kawai, T. J. Am. Chem. Soc. 2012, 134, 19877-19883.
   
   
6. Maintenance of the Secondary Structure of Horse Cytochrome c during the Conversion Process of Monomers to Oligomers by Addition of Ethanol
   Hirota, S.; Ueda, M.; Hayashi, Y.; Nagao, S.; Kamikubo, H.; Kataoka, M. J. Biochem. 2012, 152, 521-529.
   
   
7. Field-dependent ¹⁹F NMR Study of Sperm Whale Myoglobin Reconstituted with Ring-fluorinated Heme
   Yamamoto, Y.; Nagao, S.; Hirai, Y.; Tai, H.; Suzuki, A. Polymer J. 2012, 44, 907-912.
   
   
8. Reaction Pathway and Free Energy Profile for Conversion of pi-Conjugation Modes in Porphyrin Isomer
   Matsuo, T.; Tohi, Y.; Hayashi, T. J. Org. Chem. 2012, 77, 8946-8955.
   　　　　
   
9. Reaction of Cobalt Porphycene with Hydride Reagents: Spectroscopic Detection of Co–H Porphycene Species and Formation of Co–SnR₃ Porphycene Species
   Matsuo, T.; Komatsuzaki, K.; Tsuji, T.; Hayashi, T. J. Pophyrins. Phthalocyanines. 2012, 16, 616-625.
   
   
10. Synthesis of Rhenium(I) Tricarbonyl Complexes with Carbohydrate-Pendant Tridentate Ligands and their Cellular Uptake
    Mikata, Y.; Takahashi, K.; Noguchi, Y.; Naemura, M.; Ugai, A.; Itami, S.; Yasuda, K.; Tamotsu, S.; Matsuo, T.; Storr, T. Eur.J. Inorg. Chem. 2012, 217-225.
    
    

著書

1. 第5章生物に学び，次代を拓く, 3 光応答性分子の生体系への利用
   廣田俊, 松尾貴史, 光エネルギー革命：グリーンフォトニクス, 河合壯, 中村雅一, 細川陽一郎監修・編纂, ケイ・ディー・ネオブック, 京都, 2012, pp 98-106.
   

解説

1. シトクロムcポリマー：水溶性球状タンパク質に見出された多量化機構
   廣田俊, 樋口芳樹, 日本結晶学会誌,2012, 54,270-275.
   

1. Supramolecular Organization of Light-Harvesting Porphyrin Macrorings
   Satake, A.; Azuma, S.; Kuramochi, Y.; Hirota, S.; Kobuke, Y. Chem. Eur. J. 2011, 17, 855-865.
   
   
2. Enhancement of Laccase Activity through the Construction and Breakdown of a Hydrogen Bond at the Type I Copper Center in Escherichia coli CueO and the Deletion Mutant Δα5-7 CueO
   Kataoka, K.; Hirota, S.; Maeda, Y.; Kogi, H.; Shinohara, N.; Sekimoto, M.; Sakurai, T. Biochemistry 2011, 50, 558-565.
   
   
3. Post-translational His-Cys Cross-Linkage Formation in Tyrosinase Induced by Copper(II)-Peroxo Species
   Fujieda, N.; Ikeda, T.; Murata, M.; Yanagisawa, S.; Aono, S.; Okubo, K.; Nagao, S.; Ogura, T.; Hirota, S.; Fukuzumi, S.; Nakamura, Y.; Hata, Y.; Itoh, S. J. Am. Chem. Soc. 2011, 133, 1180-1183.
   
   
4. Efficient Reduction of Cys110 Thiyl Radical by Glutathione in Human Myoglobin
   Nagao, S.; Asami, O.; Yasui, H.; Hirota, S. Biochim. Biophys. Acta – Proteins and Proteomics 2011, 1814, 480-486.
   
   
5. Peroxidase Activity Enhancement of Horse Cytochrome c by Dimerization
   Wang, Z.; Matsuo, T.; Nagao, S.; Hirota, S. Org. Biomol. Chem. 2011, 9, 4766-4769.
   
   
6. DNA Cleavage by the Photocontrolled Cooperation of ZnII Centers in an Azobenzene-Linked Dizinc Complex
   Panja, A.; Matsuo, T.; Nagao, S.; Hirota, S. Inorg. Chem. 2011, 50, 11437-11445.
   
   
7. Thermal Isomerization of N-Bridged Cobalt Corrole Complexes through Transiently Formed Axial Carbenoid
   Chattopadhyay, P.; Matsuo, T; Tsuji, T.; Ohbayashi, J.; Hayashi, T. Organometallics 2011, 30, 1869-1873.
   
   
8. Precise Design of Artificial Cofactors for Enhancing Peroxidase Activity of Myoglobin: Myoglobin Mutant H64D Reconstituted with a Single-winged Cofactor is Equivalent to Native Horseradish Peroxidase in Oxidation Activity
   Matsuo, T; Fukumoto, K.; Watanabe, T.; Hayashi, T. Chem. Asian. J. 2011, 6, 2491-2499. [INSIDE COVER FIGURE]
   　　　　
   
9. Investigation of Aromaticity and Photophysical Properties in [18]/[20]pi-Porphycene Derivatives
   Kim, K. S.; Sung, Y. M.; Matsuo, T.; Hayashi, T.; Kim, D. Chem. Eur. J. 2011, 17, 7882-7889.
   　　　　
   　　　　
   

解説

1. Structures of Dimeric and Trimeric Cytochrome c and Its Polymerization Mechanism
   Hirota, S.; Higuchi, Y. Spring-8 Research Frontiers 2011, 32-33.
   

1. Supramolecular Protein–Protein Complexation via Specific Interaction Between Glycosylated Myoglobin and Sugar-binding Protein
   Nagai, H.; Onoda, A.; Matsuo, T.; Hayashi, T. Supramol. Chem. 2010, 22, 57-64.
   
   
2. Reduction of Bis(dithiolene)oxo(disulfido)tungsten(VI) Complex with Dihydrogen Related to the Chemical Function of the Fourth Tungsten–Containing Enzyme (WOR4) from Pyrococcus furiosus
   Sugimoto, H.; Tano, H.; Toyota, K.; Tajima, R.; Miyake, H.; Takahashi, I.; Hirota, S.; Itoh, S. J. Am. Chem. Soc. 2010, 132, 8-9.
   
   
3. Effect of Heme Modification on Oxygen Affinity of Myoglobin and Equilibrium of the Acid-Alkaline Transition in Metmyoglobin
   Shibata, T.; Nagao, S.; Fukaya, M.; Tai, H.; Nagatomo, S.; Morihashi, K.; Matsuo, T.; Hirota, S.; Suzuki, A.; Imai, K.; Yamamoto, Y. J. Am. Chem. Soc. 2010, 132, 6091-6098.
   
   
4. Coherent Dynamics and Ultrafast Excited State Relaxation of Blue Copper Protein; Plastocyanin
   Nagasawa, Y.; Fujita, K.; Katayama, T.; Ishibashi, Y.; Miyasaka, H.; Takabe, T.; Nagao, S; Hirota, S. Phys. Chem. Chem. Phys. 2010, 12, 6067-6075.
   
   
5. Structural Basis of the Lactate-Dependent Allosteric Regulation of Oxygen Binding in Arthropod Hemocyanin
   Hirota, S.; Tanaka, N.; Micetic, I.; Di Muro, P.; Nagao, S.; Kitagishi, H.; Kano, K.; Magliozzo, R. S.; Peisach, J.; Beltramini, M.; Bubacco, L. J. Biol. Chem. 2010, 285, 19338-19345.
   
   
6. Characterization of the Acid–alkaline Transition in the Individual Subunits of Human Adult and Foetal Methaemoglobins
   Shibata, T.; Nagao, S.; Tai, H.; Nagatomo, S.; Hamada, H.; Yoshikawa, H.; Suzuki, A.; Yamamoto, Y. J. Biochem. 2010, 148, 217-229.
   
   
7. Cytochrome c Polymerization by Successive Domain Swapping at the C-Terminal Helix
   Hirota, S.; Hattori, Y.; Nagao, S. Taketa, M.; Komori, H.; Kamikubo, H.; Wang, Z.; Takahashi, I.; Negi, S.; Sugiura, Y.; Kataoka, M.; Higuchi, Y. Proc. Natl. Acad. Sci. USA 2010, 107, 12854-12859.
   
   
8. Crystallization and Preliminary X-ray Analysis of Dimeric and Trimeric Cytochromes c from horse Heart
   Taketa, M.; Komori, H.; Hattori, Y.; Nagao, S.; Hirota, S.; Higuchi, Y. Acta. Crystallogr. Sect. F 2010, 66, 1477-1479.
   
   
9. New Class of Rhodamine Luminophore: Design, Syntheses and Aggregation-Induced Emission Enhancement
   Kamino, S.; Horio, Y.; Komeda, S.; Minoura, K.; Ichikawa, H.; Horigome, J.; Tatsumi, A.; Kaji, S.; Yamaguchi, T.; Usami, Y.; Hirota, S.; Enomoto, S.; Fujita, Y. Chem. Commun. 2010, 46, 9013-9015.
   
   
10. Oxoferryl Porphyrin/Hydrogen Peroxide System Whose Behavior is Equivalent to Hydroperoxoferric Porphyrin
    Kitagishi, H.; Tamaki, M.; Ueda, T.; Hirota, S.; Ohta, T.; Naruta, Y.; Kano, K. J. Am. Chem. Soc. 2010, 132, 16730–16732.
    
    

著書

1. 生命錯体無機化学のサブノート
   廣田俊, 安井裕之共著, 京都廣川書店, 東京, 2010.

総説

1. 光で生体関連分子の構造を制御する
   廣田俊, 現代化学10月号, 東京化学同人, 2010, 475, 36-40.
   

1. A Role of the Heme-7-Propionate Side Chain in Cytochrome P450cam as a Gate for Regulating the Access of Water Molecules to the Substrate-Binding Site
   Hayashi, T.; Harada, K.; Sakurai, K.; Shimada, H.; Hirota, S. J. Am. Chem. Soc. 2009, 131, 1398-1400.
   
   
2. Four-Electron Reduction of Dioxygen by a Multicopper Oxidase, CueO, and Roles of Asp112 and Glu506 Located Adjacent to the Trinuclear Copper Center
   Kataoka, K.; Sugiyama, R.; Hirota, S.; Inoue, M.; Urata, K; Minagawa, Y.; Seo, D.; Sakurai, T. J. Biol. Chem., 2009 284, 14405-14413.
   
   
3. Modulation of Protein-Ligand Interactions by Photocleavage of a Cyclic Peptide using Phosphatidylinositol 3-Kinase SH3 Domain as Model System
   Takahashi, I.; Kuroiwa, S.; Lindfors, H.; Ndamba, L. A.; Hiruma, Y.; Yajima, T.; Okishio, N.; Ubbink, M.; Hirota, S. J. Petp. Sci. 2009, 15, 411-416.
   
   
4. Electron Transfer from Cytochrome c to Cupredoxin
   Takayama, S. J.; Irie, K.; Tai, H.; Kawahara, T.; Hirota, S.; Takabe, T.; Alcaraz, J. A.; Donaire, A.; Yamamoto, Y. J. Biol. Inorg. Chem. 2009, 14, 821-828.
   
   
5. Regulating Copper-Binding Affinity with Photoisomerizable Azobenzene Ligand by Construction of a Self-Assembled Monolayer
   Takahashi, I; Honda, Y.; Hirota, S. Angew. Chem. Int. Ed. 2009, 48, 6065-6068.
   
   
6. Coordination-induced sliding motion of a complementary porphyrin-phthalocyanine dimer: fluorescence-based molecular switch
   Satake, A.; Sugimura, T.; Kobuke, Y. J. Porphyrins Phthalocyanines 2009, 13, 326-335.
   
   
7. Energy transfer followed by electron transfer in a porphyrin macrocycle and central acceptor ligand: A model for a photosynthetic composite of the light-harvesting complex and reaction center
   Kuramochi, Y.; Sandanayaka, Atula S. D.; Satake, A.; Araki, Y.; Ogawa, K.; Ito, O.; Kobuke, Y. Chem. Eur. J. 2009, 15, 2317-2327.
   
   
8. Single Supramolecular Porphyrin Wires Bridging Gold Nanoparticles
   Satake, A.; Fujita, M.; Kurimoto, Y.; Kobuke, Y. J. Inorg. Chem. 2009, 1231-1233.
   
   
9. Meso-Unsubstituted Iron Corrole in Hemoproteins: Remarkable Differences in Effects on Peroxidase Activities　between Myoglobin and Horseradish Peroxidase
   Matsuo, T.; Hayashi, A.; Abe, M.; Matsuda, T.; Hisaeda Y.; Hayashi, T. J. Am. Chem. Soc. 2009, 131, 15124-15125.
   
   

著書

1. 元素１１１の新知識　第２版
   桜井弘編, 廣田俊 他 著, 講談社, 東京, 2009.

総説

1. Electron Transfer and Oxidation Activities in Reconstituted Hemoproteins　with Chemically Modified Cofactor
   Matsuo, T.; Hayashi, T. J. Porphyrins Phthalocyanines 2009, 13, 1082-1089.
   

特許

1. リンカーを有するアゾ化合物及び当該アゾ化合物を用いた金属イオン回収方法
   発明者：廣田俊, 高橋勇雄, 本田裕一朗, 出願番号：特願2009-52285 (2009).
   
   

2008年


原著論文

1. Evaluation of the Functional Role of the Heme-6-Propionate Side Chain in Cytochrome P450cam
   Harada, K.; Sakurai, K.; Ikemura, K.; Ogura, T.; Hirota, S.; Shimada, H.; Hayashi, T. J. Am. Chem. Soc. 2008, 130, 432-433.
   
   
2. H-atom Abstraction Reaction for Organic Substrates via Mononuclear Copper(II)-Superoxo Species as a Model for DbM and PHM
   Fujii, T.; Yamaguchi, S.; Hirota, S.; Masuda, H. Dalton Trans 2008, 164-170.
   
   
3. Development of Novel Water-Soluble Photocleavable Protective Group and Its Application for Design of Photoresponsive Paclitaxel Prodrugs
   Noguchi, M.; Skwarczynski, M.; Prakash, H.; Hirota, S.; Kimura, T.; Hayashi, Y.; Kiso, Y. Bioorg. Med. Chem. 2008, 16, 5389-5397.
   
   
4. Thermodynamics of Apoplastocyanin Folding: Comparison between Experimental and Theoretical Results
   Yoshidome, T.; Kinoshita, M.; Hirota, S.; Baden, N.; Terazima, M. J. Chem. Phys. 2008, 128, 225104.
   
   
5. Photocontrol of Spatial Orientation and DNA Cleavage Activity of Copper(II)-Bound Dipeptides Linked by an Azobenzene Derivative
   Prakash, H.; Shodai, A.; Yasui, H.; Sakurai, H.; Hirota, S. Inorg. Chem. 2008, 47, 5045-5047.
   
   
6. A Supramolecular Receptor of Diatomic Molecules (O2, CO, NO) in Aqueous Solution
   Kano, K.; Itoh, Y.; Kitagishi, H.; Hayashi, T.; Hirota, S. J. Am. Chem. Soc. 2008, 130, 8006-8015.
   
   
7. Stable Supramolecular Complex of Porphyrin Macroring with Pyridyl and Fullerenyl Ligands
   Zafer, U.; Satake, A.; Kobuke, Y.; Hirota, S. Tetrahedron Lett. 2008, 49, 5484-5487.
   
   
8. Syntheses, Characterization and Reactivities of μ-η2:η2-Disulfidodicopper(II) Complexes with N-Alkylated cis,cis-1,3,5-Triamionocyclohexane Derivatives
   Kajita, Y.; Matsumoto, J.; Takahashi, I.; Hirota, S.; Funahashi, Y.; Ozawa, T.; Masuda, H., Eur. J. Inorg. Chem. 2008, 3977-3986.
   
   
9. A New Class of Sulfido/oxo(dithiolene)–molybdenum(IV) Complexes Derived from Sulfido/Oxo–Bis(tetrasulfido)molydebnum(IV) Anions
   Sugimoto, H.; Suyama, K.; Sugimoto, K.; Miyake, H.; Takahashi, I.; Hirota, S.; Itoh, S. Inorg. Chem. 2008, 47, 10150-10157.
   
   
10. Molecular Basis of the Bohr Effect in Arthropod Hemocyanin
    Hirota, S.; Kawahara, T.; Beltramini, M.; Di Muro, P.; Magliozzo, R. S.; Peisach, J.; Powers, L. S.; Tanaka, N.; Nagao, S.; Bubacco, L. J. Biol. Chem. 2008, 283, 31941-31948.
    
    
11. Construction of Giant Porphyrin Macrorings Self-Assembled from Thiophenylene-Linked Bisporphyrins for Light-Harvesting Antenna
    Fujisawa, K.; Satake, A.; Hirota, S.; Kobuke, Y. Chem. Eur. J. 2008, 14, 10735-10744.
    
    
12. Formation of a Bridged Butterfly-Type μ-η2:η2-Peroxo Dicopper Core Structure with a Carboxylate Group
    Funahashi, Y.; Nishikawa, T.; Wasada-Tsutsui, Y.; Kajita, Y.; Yamaguchi, S.; Arii, H.; Ozawa, T.; Jitsukawa, K.; Tosha, T.; Hirota, S.; Kitagawa, T.; Masuda, H. J. Am. Chem. Soc. 2008, 130, 16444-16445.
    
    
13. Controlled Production of Amyloid β Peptide from a Photo-Triggered, Water-Soluble Precursor "Click Peptide"
    Taniguchi, A.; Skwarczynski, M.; Sohma, Y.; Okada, T.; Ikeda, K.; Prakash, H.; Mukai, H.; Hayashi, Y.; Kimura, T.; Hirota, S.; Matsuzaki, K.; Kiso, Y. ChemBioChem 2008, 9, 3055-3065.
    
    
14. Oxidation of Adamantane Catalysed by Imidazolylporphyrinatoiron(III) Complexes and Structural Studies of 5-Coordinating Iron(III) Porphyrin,
    Miyazaki, Y.; Satake, A.; Kobuke, Y. J. Mol. Cat. A: Chemical 2008, 283, 129-139.
    
    
15. Light-Harvesting Supramolecular Porphyrin Macroring Accommodating a Fullerene–Tripodal Ligand,
    Kuramochi, Y.; Satake, A.; Itou, M.; Ogawa, K.; Araki, Y.; Ito, O.; Kobuke, Y. Chem. Eur. J. 2008, 14, 2827-2841.
    
    
16. Transmembrane Nanopores from Porphyrin Supramolecules
    Satake, A.; Yamamura, M.; Oda, M.; Kobuke, Y. J. Am. Chem. Soc. 2008, 130, 6314-6315.
    
    
17. Recent Advances in Two-photon Photodynamic Therapy
    Ogawa, K.; Kobuke, Y. Curr. Med. Chem. - Anti-Cancer Agents 2008, 8, 269-279.
    
    
18. Stepwise Elongation Effect on the Two-photon Absorption of Self-assembled Butadiyne Porphyrins
    Dy, J. T.; Ogawa, K.; Kamada, K.; Ohta, K; Kobuke, Y. Chem. Commun. 2008, 3411-3413.

著書

1. 生命錯体化学
   廣田俊, 安井裕之著, 京都廣川書店, 東京, 2008.

総説

1. 光応答性タンパク質・ペプチドの創製と構造制御
   廣田俊, 生命化学研究レター, 生命化学研究会, 2008, 27, 10-15.

2007年


原著論文

1. Structure and Ligand Binding Properties of Myoglobins Reconstituted with Monodepropionated Heme: Functional Role of Each Heme-Propionate Side Chain
   Harada, K.; Makino, M.; Sugimoto, H.; Hirota, S.; Matsuo, T.; Shiro, Y.; Hisaeda, Y.; Hayashi, T. Biochemistry 2007, 46, 9406-9416.
   
   
2. Trapping of a Dopaquinone Intermediate in the TPQ Cofactor Biogenesis in a Copper-containing Amine Oxidase from Arthrobacter globiformis
   Moore, R. H.; Spies, M. A.; Culpepper, M. B.; Murakawa, T.; Hirota, S.; Okajima, T.; Tanizawa, K.; Mure, M. J. Am. Chem. Soc. 2007, 129, 11524-11534.
   
   
3. Thermodynamical Properties of Reaction Intermediates during Apoplastocyanin Folding in Time-Domain
   Baden, N.; Hirota, S.; Takabe, T.; Funasaki, N.; Terazima, M. J. Chem. Phys. 2007, 127, 175103 (12 pages).
   
   
4. A Photochromic Porphyrin-perinaphthothioindigo Conjugate and its Two-photon Absorption Properties
   Dy, J. T.; Maeda, R.; Nagatsuka, Y.; Ogawa, K.; Kamada, K.; Ohta, K.; Kobuke, Y.  Chem. Commun. 2007, 5170-5172.
   
   
5. Syntheses and Properties of Acetylene-linked Bis- and Trisporphyrins toward Two-photon Photodynamic Therapy
   Inaba, Y.; Ogawa, K.; Kobuke, Y. J. Porphyrins Phthalocyanines 2007, 11, 406-417.
   
   
6. Syntheses and Nonlinear Absorption Properties of Conjugated Porphyrin Supramolecules
   Ogawa, K.; Hara, C.; Kobuke, Y. J. Porphyrins Phthalocyanines 2007, 11, 359-367.
   
   
7. Ligand-Induced Interconversion of a Coordination-Organized Porphyrin Dimer: a Potential Fluorescence-based Molecular Memory Monitor,
   Satake, A.; Tanihara, J.; Kobuke, Y. Inorg. Chem. 2007, 46, 9700-9707.
   
   
8. Water-soluble Self-assembled Butadiyne-bridged Bisporphyrin: a Potential Two- Photon Absorbing Photosensitizer for Photodynamic Therapy
   Dy, J.; K. Ogawa, K.; Satake, A.; Ishizumi, A.; Kobuke, Y. Chem. Eur. J. 2007, 13, 3491-3500.
   
   
9. Singlet Oxygen Generation and Photocytotoxicity against Tumor Cell by Two-Photon Absorption
   Ogawa, K.; Dy, J.; Kobuke, Y.; Ogura, S.; Okura, I. Mol. Cryst. Liq. Cryst. 2007, 471, 61-67.
   
   
10. Supramolecular Array of Imizazolylethynyl-zinc-porphyrin,
    Satake, A.; Shoji, O.; Kobuke, Y. J. Organomet. Chem. 2007, 69, 635-644.
    
    
11. Heme Orientational Disorder in Human Adult Hemoglobin Reconstituted with a Ring Fluorinated Heme and Its Functional Consequences
    Nagao S.; Hirai Y.; Kawano S.; Imai K.; Suzuki A.; Yamamoto Y. Biochem. Biophys. Res. Commun. 2007, 354, 681-685.

著書

1. 自由エネルギーと化学ポテンシャル
   廣田俊, 薬学教科書シリーズ 物理化学，杉浦幸雄，野村靖幸，夏苅英昭，平井みどり編，化学同人，2007, pp 65-76.
   
   
2. 化学平衡
   廣田俊, 薬学教科書シリーズ 物理化学，杉浦幸雄，野村靖幸，夏苅英昭，平井みどり編，化学同人，2007, pp 77-86.
   
   
3. 相平衡
   廣田俊, 薬学教科書シリーズ 物理化学，杉浦幸雄，野村靖幸，夏苅英昭，平井みどり編，化学同人，2007, pp 87-105.

総説

1. タンパク質構造変化の新規計測法の開発
   廣田俊, Pharma VISION NEWS, 日本薬学会薬学研究ビジョン部会, 2007, 10, 17-21.
   
   
2. Assemblies of Porphyrins and Phthalocyanines Showing Strong Electronic　Coupling
   Satake A.; Kobuke, Y. Organic and Bioorganic Chemistry,2007, 5, 1679-1691.
   
   
3. 遷移金属錯体を用いたポルフィリンの機能化と多量化－巨大機能性分子系の構築と課題
   佐竹彰治，有機合成化学協会誌，2007, 65,　298-307.
   
   
4. Supramolecular Porphyrin Systems by Self-organization for Nano-photonic Device
   Kobuke, Y.; Satake, A.; Ogawa, K. in BOTTOM-UP NANOFABRICATION: Supramolecules, Self-Assemblies, and Organized Films, 2007, Chapter 16, 1-27.
   
   
5. ポルフィリン化合物の二光子吸収
   小川和也, 小夫家芳明, 科学と工業, 2007, 81, 25-30.
   
   
6. イミダゾリルポルフィリンのナノ自己組織配位体
   佐竹彰治，小夫家芳明, 有機エレクトロニクスにおける分子配向技術, 第7章　ナノスケールでの分子配向, 内藤裕義，久保野敦史，舟橋正浩，吉本尚起 監修、シーエムシー出版、2007, 322-328.

特許

1. アゾペプチド複合体
   発明者：廣田俊, ハランプラカシュ, 出願番号：特願2007-179592 (2007).
   
   
2. ポルフィリン化合物、ポルフィリン化合物の製造方法、三次元光記録材料および三次元光記録媒体
   発明者：小夫家芳明, 小川和也, 平成19 年1 月9 日, 出願番号：特願2007-001730 (2007).
   
   
3. ポルフィリン化合物、ポルフィリン化合物の製造方法、三次元光記録材料および三次元光記録媒体
   発明者：小夫家芳明, 小川和也, 平成19 年1 月9 日, 米国出願 (2007).

2006年


原著論文

1. Chemical Shifts as a Novel Measure of Interactions between Two Binding Sites of Symmetric Dialkyldimethylammonium Bromides to α-Cyclodextrin
   Funasaki, N.; Ishikawa, S.; Hirota, S. Anal. Chim. Acta 2006, 555, 278-285.
   
   
2. "Click Peptide" Based on the "O-Acyl Isopeptide Method": Control of Aβ1-42 Production from a Photo-Triggered Aβ1-42 Analogue
   Taniguchi, A.; Sohma, Y.; Kimura, M.; Okada, T.; Ikeda, K.; Hayashi, Y.; Kimura, T.; Hirota, S.; Matsuzaki, K.; Kiso, Y. J. Am. Chem. Soc. 2006, 128, 696-697.
   
   
3. Molecular Motions of α-Cyclodextrin on a Dodecyl Chain Studied by Molecular Dynamics Simulations
   Ishikawa, S.; Hirota, S.; Neya, S.; Funasaki, N. Chem. Pharm. Bull. 2006, 54, 528-534.
   
   
4. Kinetic and Structural Studies on the Catalytic Role of the Aspartic Acid Residue Conserved in Copper Amine Oxidase
   Chiu, Y.-C.; Okajima, T.; Murakawa, T.; Uchida, M.; Taki, M.; Hirota, S.; Kim, M.; Yamaguchi, H.; Kawano, Y.; Kamiya, N.; Kuroda, S.; Hayashi, H.; Yamamoto, Y.; Tanizawa, K. Biochemistry 2006, 45, 4105-4120.
   
   
5. Iron Porphyrin-Cyclodextrin Supramolecular Complex as a Functional Model of Myoglobin in Aqueous Solution
   Kano, K.; Kitagishi, H.; Dagallier, C.; Kodera, M.; Matsuo, T.; Hayashi, T.; Hisaeda, Y.; Hirota, S. Inorg. Chem. 2006, 45, 4448-4460.
   
   
6. Micelle Formation of Bile Salts and Zwitterionic Derivative as Studied by Two-Dimensional NMR Spectroscopy
   Funasaki, N.; Fukuba, M.; Hattori, T.; Ishikawa, S.; Okuno, T.; Hirota S. Chem. Phys. Lipids 2006, 142, 43-57.
   
   
7. Conformational Changes during Apoplastocyanin Folding Observed by Photocleavable Modification and Transient Grating
   Hirota, S.; Fujimoto, Y.; Choi, J.; Baden, N.; Katagiri, N.; Akiyama, M.; Hulsker, R.; Ubbink, M.; Okajima, T.; Takabe, T.; Funasaki, N.; Watanabe, Y.; Terazima, M. J. Am. Chem. Soc. 2006, 128, 7551-7558.
   
   
8. Development of First Photoresponsive Prodrug of Paclitaxel
   Skwarczynski, M.; Noguchi, M.; Hirota, S.; Sohma, Y.; Kimura, T.; Hayashi, Y.; Kiso, Y. Bioorg. Med. Chem. Lett. 2006, 16, 4492-4496.
   
   
9. Masking Mechanisms of Bitter Taste of Drugs Studied with Ion Selective Electrodes
   Funasaki, N.; Uratsuji, I.; Okuno, T.; Hirota, S.; Neya, S. Chem. Pharm. Bull. 2006, 54, 1155-1161.
   
   
10. A Myoglobin Functional Model Composed of a Ferrous Porphyrin and a Cyclodextrin Dimer with an Imidazole Linker
    Kano, K.; Kitagishi, H.; Mabuchi, T.; Kodera, M.; Hirota, S. Chem. Asian J. 2006, 1, 358-366.
    
    
11. Reduction of Plastocyanin by Tyrosine-Containing Oligopeptides
    Hirota, S.; Okumura, H.; Kondoh, T.; Funasaki, N.; Takabe, T.; Watanabe, Y. J. Inorg. Biochem. 2006, 100, 1871-1878.
    
    
12. 'Click peptide’: a novel ‘O-acyl isopeptide method’ for peptide synthesis and chemical biology-oriented synthesis of amyloid βpeptide analoguesShoma, Y.; Taniguchi, A.; Yoshiya, T.; Chiyomori, Y.; Fukao, F.; Nakamura, S.; Skwarczynski, M.; Okada, T.; Ikeda, K.; Hayashi, Y.; Kimura, T.; Hirota, S.; Matsuzaki, K.; Kiso, Y. J. Pept. Sci. 2006, 12, 823–828.
    
    
13. Direct Observation of Photoinduced Electron Transfer in Zinc Porphyrin / Zinc Phthalocyanine Composite
    Ito, F.; Ishibashi, Y.; Khan, S. R.; Miyasaka, H.; Kameyama, K.; Morisue, M.; Satake, A.; Ogawa, K.; Kobuke, Y. J. Phys. Chem. A 2006, 110, 12734-12742.
    
    
14. Construction and Photophysical Properties of Self-assembled Linear Porphyrin Arrays
    Ogawa, K.; Kobuke, Y. J. Photochem. Photobiol. C 2006, 7, 1-16.
    
    
15. Single molecular observation of penta- and hexagonic assembly of bisporphyrin on a gold surface
    Satake, A.; Tanaka, H.; Hajjaj, F.; Kawai, T.; Kobuke, Y. Chem. Commun. 2006, 2542-2544.
    
    
16. A Supramolecular Photosynthetic Triad of Slipped Cofacial Porphyrin Dimer, Ferrocene, and Fullerene
    Nakagawa, H.; Ogawa, K.; Satake, A.; Kobuke, Y. Chem. Commun. 2006, 1560-1562.
    
    
17. Assemblies of Supramolecular Porphyrin Dimers in Pentagonal and Hexagonal Arrays Exhibiting Light-Harvesting Antenna Function
    Hajjaj, F.; Yoon, Z. S.; Yoon, M.-C.; Park, J.; Satake, A.; Kim, D.; Kobuke, Y. J. Am. Chem. Soc. 2006, 128, 4612-4623.
    
    
18. Water-Soluble Bis(imidazolylporphyrin) Self-Assemblies with Large Two-Photon Absorption Cross Sections as Potential Agents for Photodynamic Therapy
    Ogawa, K.; Hasegawa, H.; Inaba, Y.; Kobuke, Y.; Inouye, H.; Kanemitsu, Y.; Kohno, E.; Hirano, T.; Ogura, S.; Okura, I. J. Med. Chem. 2006, 49, 2276-2283.
    
    
19. Two-photon Absorption Properties of Conjugated Supramolecular Porphyrins with Electron Donor and Acceptor
    Tanihara, J.; Ogawa, K.; Kobuke, Y. J. Photochem. Photobiol. A 2006, 178, 140-149.
    
    
20. Synthesis of Hexazincporphyrin and Hexaamine Substituted Ru(bipy)3 Complexes for Alternate Self-Assembly by Tritopic Coordinations
    Fukuda, S.; Satake, A.; Kobuke, Y. Thin Solid Films 2006, 499, 263-268.

著書

1. 2.2.7 鉄
   廣田俊, 生命元素の辞典 第2章 主要元素、微量元素、および、生体機能にかかわる元素 2.2 必須微量元素, 桜井弘編, オーム社, 2006, pp 78–81.
   
   
2. 2.2.8 コバルト
   廣田俊, 生命元素の辞典 第2章 主要元素、微量元素、および、生体機能にかかわる元素 2.2 必須微量元素, 桜井弘編, オーム社, 2006, pp 82–85.
   
   
3. 4.2.3 赤外スペクトル・ラマンスペクトル
   廣田俊, 生命元素の辞典 第4章 微量元素の研究法 4.2 構造解析法, 桜井弘編, オーム社, 2006, pp 386–390.

総説

1. ¹⁹F NMR Study of b-Type Haemoproteins
   Yamamoto Y; Nagao S.; Suzuki A. Modern Magnetic Resonance, Webb, G. A. Ed., Springer, 2006, pp.527-534.

特許

1. π系が直接結合したポルフィリン－フタロシアニン二量体及び四量体並びにそれらの製造方法
   発明者：小夫家芳明, 佐竹彰治, 小川和也, 平成18年5月17日, EPC, アメリカ, 中国出願(2006).
   
   
2. ポルフィリン化合物及びその利用
   発明者：小夫家芳明, 小川和也, 平成18年3月7日, 出願番号：特願2006-084749 (2006).
   
   
3. ポルフィリン化合物及びその利用
   発明者：小夫家芳明, 小川和也, 平成18年3月27日, ＰＣＴ国際出願(2006).
   
   
4. π系が直接結合したポルフィリン－フタロシアニン二量体及び四量体並びにそれらの製造方法
   発明者：小夫家芳明, 佐竹彰治, 小川和也, 平成18年3月6日, 出願番号：特願2005-515944 (2006).