before 2012


Original papers
  1. Formation and Carbon Monoxide-Dependent Dissociation of Allochromatium vinosum Cytochrome c’ Oligomers Using Domain-Swapped Dimers
    Yamanaka, M.; Hoshizumi, M.; Nagao, S.; Nakayama, R.; Shibata, N.; Higuchi, Y.; Hirota, S. Protein Sci. 2017, 26(3), 464-474.

  2. Improved Stopped-Flow Time-Resolved Resonance Raman Spectroscopy Device for Studying Enzymatic Reactions
    Yanagisawa, S. Deshpande, M. S.; Hirota, S.; Nakagawa, T.; Ogura, T. J. Raman Spectrosc. 2017, 48(5), 680-685.

  3. Difference in NaCl Tolerance of Membrane-bound 5'-nucleotidases Purified from Deep-sea and Brackish Water Shewanella Species
    Kuribayashi TA, Fujii S, Masanari M, Yamanaka M, Wakai S, Sambongi Y. Extremophiles. 2017, 21(2), 357-368.

  4. Structural and Functional Insights into Thermally Stable Cytochrome c' from a Thermophile
    Fujii, S.; Oki, H.; Kawahara, K.; Yamane, D.; Yamanaka, M.; Maruno, T.; Kobayashi, Y.; Masanari, M.; Wakai, S.; Nishihara, H.; Ohkubo, T.; Sambongi, Y. Protein Sci. 2017, 26(4), 737-748

  5. Effect of Methionine80 Heme Coordination on Domain Swapping of Cytochrome c
    Hirota, S.; Yamashiro, N.; Wang, Z.; Nagao, S. J. Biol. Inorg. Chem. 2017, 22(5), 705-712.

  6. A Single Spherical Assembly of Protein Amyloid Fibrils Formed by Laser Trapping
    Yuyama, K.; Ueda, M.; Nagao, S.; Hirota, S.; Sugiyama, T.; Masuhara, H. Angew. Chem. Int. Ed. 2017, 56(24), 6739-6743. Selected as "Hot Paper".

  7. Structural Basis of the Redox Switches in the NAD+-Reducing Soluble [NiFe]-Hydrogenase
    Shomura, Y.; Taketa, M.; Nakashima, H.; Tai, H.; Nakagawa, H.; Ikeda, Y.; Ishii, M.; Igarashi, Y.; Nishihara, H.; Yoon, K.-S.; Ogo, S.; Hirota, S.; Higuchi, Y. Science 2017, 357(6354), 928-932.

  8. Rational Design of Domain-Swapping-Based c-Type Cytochrome Heterodimers by Using Chimeric Proteins
    Zhang, M.; Nakanishi, T.; Yamanaka, M.; Nagao, S.; Yanagisawa, S.; Shomura, Y.; Shibata, N.; Ogura, T.; Higuchi, Y.; Hirota, S. ChemBioChem 2017, 18(17), 1712-1715.

  9. Equilibrium between Inactive Ready Ni-SIr and Active Ni-SIa States of [NiFe] Hydrogenase Studied by Utilizing Ni-SIr-to-Ni-SIa Photoactivation
    Tai, H.; Xu, L.; Nishikawa, K.; Higuchi, Y.; Hirota, S. Chem. Commun 2017, 53, in press.

  10. Activation Mechanism of Streptomyces Tyrosinase Assisted by the Caddie Protein
    Matoba, Y.; Kihara, S.; Muraki, Y.; Bando, N.; Yoshitsu, H.; Kuroda, T.; Sakaguchi, M.; Kayama, K.; Tai, H.; Hirota, S.; Ogura, T.; Sugiyama, M. Biochemistry 2017, 56, in press.

  11. Hydrophobicity of Residue 128 of the Stress-Inducible Sigma Factor RpoS Is Critical for Its Activity
    Iwase, T.; Matsuo, T.; Nishioka, S.; Tajima, A.; Mizunoe, Y. Front Microbiol 2017, 8, 656.


Original papers
  1. Domain swapping oligomerization of thermostable c-type cytochrome in E. coli cells
    Hayashi, Y.; Yamanaka, M.; Nagao, S.; Komori, H.; Higuchi, Y.; Hirota, S. Sci. Rep. 2016, 6, 19334 (8 pages).

  2. Effect of Heme Electronic Structure and Distal Polar Interaction on Functional and Vibrational Properties of Myoglobin
    Kanai, Y.; Nishimura, R.; Nishiyama, K.; Shibata, T. Yanagisawa, S.; Ogura, T.; Matsuo, T.; Hirota, S.; Neya, S.; Suzuki, A.; Yamamoto, Y. Inorg. Chem. 2016, 55, 1613-1622.

  3. A Simple Interfacial pH Detection Method for Cationic Amphiphilic Self-assemblies Utilizing a Schiff-base Molecule
    Sarkar, Y. ; Das, S.; Ray, A.; Jewrajka, S. K.; Hirota, S.; Parui, P. P. Analyst 2016, 141, 2030-2039.

  4. Photoactivation of the Ni-SIr State to the Ni-SIa State in [NiFe] Hydrogenase: FT-IR Study on the Light Reactivity of the Ready Ni-SIr State and As-isolated Enzyme Revisited
    Tai, H.; Xu, L.; Nishikawa, K.; Inoue, S.; Higuchi, Y.; Hirota, S. Phys. Chem. Chem. Phys. 2016, 18, 22025 - 22030.

  5. Characterization of Cytochrome c Membrane-Binding Site Using Cardiolipin-Containing Bicelles with NMR
    Kobayashi, H.; Nagao, S.; Hirota, S. Angew. Chem. Int. Ed. 2016, 55, 14019-14022.


Original papers
  1. Rational Design of Heterodimeric Protein Using Domain Swapping for Myoglobin
    Lin, Y.-W.; Nagao, S.; Zhang, M.; Shomura, Y.; Higuchi, Y.; Hirota, S. Angew. Chem. Int. Ed. 2015, 54, 511-515.

  2. Change in Structure and Ligand Binding Properties of Hyperstable Cytochrome c555 from Aquifex aeolicus by Domain Swapping
    Yamanaka, M.; Nagao, S.; Komori, H.; Higuchi, Y.; Hirota, S. Protein Sci. 2015, 24, 366-375.

  3. Carbon Monoxide Binding Properties of Domain-Swapped Dimeric Myoglobin Nagao, S.; Ishikawa, H.; Yamada, T.; Mizutani, Y.; Hirota, S. J. Biol. Inorg. Chem. 2015, 20, 253-530.

  4. Dimer Domain Swapping versus Monomer Folding in Apo-myoglobin Studied by Molecular Simulations
    Ono, K.; Ito, M.; Hirota, S.; Takada, S. Phys. Chem. Chem. Phys. 2015, 17, 5006-5013.

  5. Excimer Emission Properties on Pyrene-labeled Protein Surface: Correlation between Emission Spectra, Ring Stacking Modes and Flexibilities of Pyrene Probes
    Fujii, A.; Sekiguchi, Y.; Matsumura, H.; Inoue, T.; Chung, WS.; Hirota, S.; Matsuo, T. Bioconjugate Chem. 2015, 26, 537-48.

  6. Domain-Swapped Dimer of Pseudomonas aeruginosa Cytochrome c551: Structural Insights into Domain Swapping of Cytochrome c Family Proteins
    Nagao, S.; Ueda, M.; Osuka, H.; Komori, H.; Kamikubo, H.; Kataoka, M.; Higuchi, Y.; Hirota, S. PLoS One 2015, 10, e0123653.

  7. Effect of a Procaspase-Activating Compound on the Catalytic Activity of Mature Caspase-3
    Matsuo, T.; Yamada, K.; Ishida, M.; Miura, Y.; Yamanaka, M.; Hirota, S. Bull. Chem. Soc. Jap. 88, 2015, 1221-1229. BCSJ award

  8. Domain-swapped Cytochrome cb562 Dimer and Its Nanocage Encapsulating a Zn–SO4 Cluster in the Internal Cavity
    Miyamoto, T.; Kuribayashi, M.; Nagao, S.; Shomura, Y.; Higuchi, Y.; Hirota, S. Chem. Sci. 2015, 6, 7336-7342.

  9. Oligomerization Enhancement and Two Domain Swapping Mode Detection for Thermostable Cytochrome c552 via the Elongation of the Major Hinge Loop
    Ren, C.; Nagao, S.; Yamanaka, M.; Komori, H.; Shomura, Y.; Higuchi, Y., Hirota, S. Mol. Biosyst. 2015, 11, 3218-3221.

  10. FT-IR Characterization of the Light-Induced Ni-L2 and Ni-L3 States of [NiFe] Hydrogenase from Desulfovibrio vulgaris Miyazaki F
    Tai, H.; Nishikawa, K.; Inoue, S.; Higuchi, Y.; Hirota, S. J. Phys. Chem. B 2015, 119, 13668-13674.


Original papers
  1. Self-Assembled Dimerization of Bis(crown ether)-2,2’-bibenzimidazoles
    Satake, A.; Tanaka, K.; Asakura, H.; Okano, M.; Hashimoto, T,; Matsuura, Y.; Inaba, Y.; Oda, T.; Hirota, S.; Koshino, H. Bull. Chem. Soc. Jpn. 2014, 87, 88-97.

  2. Electronic Control of Discrimination between O2 and CO in Myoglobin the Lacking Distal Histidine Residue
    Nishimura, R.; Shibata, T.; Ishigami, I.; Ogura, T.; Tai, H.; Nagao, S.; Matsuo, T.; Hirota, S.; Shoji, O.; Watanabe, Y.; Imai, K.; Neya, S.; Suzuki, A.; Yamamoto, Y. Inorg. Chem. 2014, 53, 1091–1099.

  3. H2O2-dependent Substrate Oxidation by an Engineered Diiron Site in a Bacterial Hemerythrin
    Okamoto, Y.; Onoda, A.; Sugimoto, H.; Takano, Y.; Hirota, S.; Kurtz, Jr., D. M.; Shiro, Y.; Hayashi T., Chem. Commun. 2014, 50, 3421-3423.

  4. Morphological Change of Cell Membrane by Interaction with Domain-Swapped Cytochrome c Oligomers
    Junedi, S.; Yasuhara, K.; Nagao, S.; Kikuchi, J., Hirota, S. ChemBioChem 2014, 15, 517-521.

  5. High Stability of Apo-Cytochrome c' from Thermophilic Hydrogenophilus thermoluteolus
    Fujii, S.; Masanari, M.; Yamanaka, M.; Wakai, S.; Sambongi, Y. Biosci. Biotechnol. Biochem., 2014, 78, 1191-1194.

  6. Formation of Domain-Swapped Oligomer of Cytochrome c from Its Molten Globule State Oligomer
    Deshpande, M. S.; Parui, P. P.; Kamikubo, H.; Yamanaka, M.; Nagao, S.; Komori, H.; Kataoka, M.; Higuchi, Y.; Hirota, S. Biochemistry 2014, 53, 4696-4703.

  7. Electronic Control of Ligand-Binding Preference of a Myoglobin Mutant
    Nishimura, R.; Matsumoto, D.; Shibata, T.; Yanagisawa, S.; Ogura, T.; Tai, H.; Matsuo, T.; Hirota, S.; Neya, S.; Suzuki, A.; Yamamoto, Y. Inorg. Chem. 2014, 53, 9156-9165.

  8. Self-Oxidation of Cytochrome c at Methionine80 with Molecular Oxygen Induced by Cleavage of the Met−Heme Iron Bond
    Wang, Z.; Ando, Y.; Nugraheni, A. D.; Ren, C.; Nagao, S.; Hirota, S. Mol. BioSyst. 2014, 10, 3130-3137.

  9. DNA Cleavage by Oxymyoglobin and Cysteine-Introduced Metmyoglobin
    Deshpande, M. S.; Junedi, S.; Prakash, H.; Nagao, S.; Yamanaka, M.; Hirota, S.Chem. Commun. 2014, 50, 15034-15036.

  10. Control of the Transition between Ni-C and Ni-SIa States by the Redox State of the Proximal Fe-S Cluster in the Catalytic Cycle of [NiFe] Hydrogenase
    Tai, H.; Nishikawa, K.; Suzuki, M.; Higuchi, Y.; Hirota, S., Angew. Chem. Int. Ed. 2014, 53, 13817-13820.

  11. Structural characterization of imidazole adducts of heme-DNA complexes
    Suzuki, Y.; Tai, H.; Saito, K.; Shibata, T.; Kinoshita, M.; Suzuki, A.; Yamamoto, Y., J. Porphyrins Phthalocyanines 2014, 18, 741-751.

  12. Effect of the electron density of the heme Fe atom on the Fe-histidine coordination bond in deoxy myoglobin
    Nishimura, R.; Shibata, T.; Tai, H.; Ishigami, I.; Yanagisawa, S.; Ogura, T.; Neya, S.; Suzuki, A.; Yamamoto, Y., Bull. Chem. Soc. Jpn. 2014, 87, 905-911.

Reviews (International achievements only)

  1. Artificial Enzymes with Protein Scaffolds: Structural Design and Modification
    Matsuo, T.; Hirota, S. Bioorg. Med. Chem. 2014, 22, 5638-5656.


Original papers
  1. Photosensitivity of the Ni-A state of [NiFe] hydrogenase from Desulfovibrio vulgaris Miyazaki F with visible light
    Osuka, H.; Shomura, Y.; Komori, H.; Shibata, N.; Nagao, S.; Higuchi, Y.; Hirota, S. Biochem. Biophys. Res. Commun. 2013, 430, 284-288.

  2. Interaction of dimeric horse cytochrome c with cyanide ion
    Nugraheni, A.D.; Nagao, S.; Yanagisawa, S.; Ogura, T.; Hirota, S. J. Biol. Inorg. Chem. 2013, 18, 383-390.

  3. Relationship between the electron density of the heme Fe atom and the vibrational frequencies of the Fe-bound carbon monoxide in myoglobin
    Nishimura, R.; Shibata, T.; Tai, H.; Ishigami, I.; Ogura, T.; Nagao, S.; Matsuo, T.; Hirota, S.; Imai, K.; Neya, S.; Suzuki, A.; Yamamoto, Y.; Inorg. Chem. 2013, 52, 3349-3355.

  4. Reversible switching of fluorophore property based on intrinsic conformational transition of adenylate kinase during its catalytic cycle
    Fujii, A.; Hirota, S.; Matsuo, T. Bioconjug. Chem. 2013, 24, 1218-1225.

  5. Effect of Added Salt on Ring-closing Metathesis Catalyzed by a Water-soluble Hoveyda-Grubbs Type Complex to Form N-Containing Heterocycles in Aqueous Media
    Matsuo, T.; Yoshida, T.; Fujii, A.; Kawahara, K.; Hirota, S. Organometallics 2013, 32, 5313-5319.

  6. Crystal Structure, Exogenous Ligand Binding and Redox Properties of an Engineered Diiron Active Site in a Bacterial Hemerythrin
    Okamoto, Y.; Onoda, A.; Sugimoto, H.; Takano, Y.; Hirota, S.; Kurtz, Jr., D. M.; Shiro, Y,; Hayashi, T. Inorg. Chem. 2013, 52, 13014-13020.
  7. Formation of Oligomeric Cytochrome c during Folding by Intermolecular Hydrophobic Interaction between N- and C-Terminal α-Helices
    Parui, P. P.; Deshpande, M. S.; Nagao, S.; Kamikubo, H.; Komori, H.; Higuchi, Y.; Kataoka, M.; Hirota, S. Biochemistry 2013, 52, 8732-8744.

  8. NMR Spectroscopic Study of the Complexation Behaviors of Deuterated Cyclodextrins and [60]Fullerene
    Ikeda, A.; Hida, T.; Kikuchi, J.; Nobusawa, K.; Matsuo, T.; Org. Lett. 2013, 15, 6194-6197.

  9. High thermal stability and unique trimer formation of cytochrome c' from thermophilic Hydrogenophilus thermoluteolus. Fujii, S.; Masanari, M.; Inoue, H.; Yamanaka, M.; Wakai, S.; Nishihara, H.; Sambongi, Y. Biosci. Biotechnol. Biochem. 2013 77, 81677-81.


Original papers
  1. Creation of an Artificial Metalloprotein with a Hoveyda-Grubbs Catalyst Moiety through the Intrinsic Inhibition Mechanism of α-Chymotrypsin
    Matsuo, T.; Imai, C.; Yoshida, T.; Saito, T.; Hayashi, T. Hirota, S. Chem. Commun. 2012, 48, 1662-1664.

  2. Structural and Oxygen Binding Properties of Dimeric Horse Myoglobin
    Nagao, S.; Osuka, H.; Yamada, T.; Uni, T.; Shomura, Y.; Higuchi, Y.; Hirota, S. Dalton Trans. 2012, 41, 11378-11385.

  3. Domain Swapping of the Heme and N-terminal α-helix in Hydrogenobacter thermophilus Cytochrome c552 Dimer
    Hayashi, Y.; Nagao, S.; Osuka, H.; Komori, H.; Higuchi, Y.; Hirota, S. Biochemistry 2012, 51, 8608-8616.

  4. Relationship between Oxygen Affinity and Autoxidation of Myoglobin
    Shibata, T.; Matsumoto, D.; Nishimura, R.; Tai, H.; Matsuoka, A.; Nagao, S.; Matsuo, T.; Hirota, S.; Imai, K.; Neya, S.; Suzuki, A.; Yamamoto, Y. Inorg. Chem. 2012, 51, 11955-11960.

  5. Efficient Oxidative Cycloreversion Reaction of Photochromic Dithiazolythiazole
    Nakashima, T.; Kajiki, Y.; Fukumoto, S.; Taguchi, M.; Nagao, S.; Hirota, S.; Kawai, T. J. Am. Chem. Soc. 2012, 134, 19877-19883.

  6. Maintenance of the Secondary Structure of Horse Cytochrome c during the Conversion Process of Monomers to Oligomers by Addition of Ethanol
    Hirota, S.; Ueda, M.; Hayashi, Y.; Nagao, S.; Kamikubo, H.; Kataoka, M. J. Biochem. 2012, 152, 521-529.

  7. Field-dependent 19F NMR Study of Sperm Whale Myoglobin Reconstituted with Ring-fluorinated Heme
    Yamamoto, Y.; Nagao, S.; Hirai, Y.; Tai, H.; Suzuki, A. Polymer J. 2012, 44, 907-912.

  8. Reaction Pathway and Free Energy Profile for Conversion of pi-Conjugation Modes in Porphyrin Isomer
    Matsuo, T.; Tohi, Y.; Hayashi, T. J. Org. Chem. 2012, 77, 8946-8955.
  9. Reaction of Cobalt Porphycene with Hydride Reagents: Spectroscopic Detection of Co–H Porphycene Species and Formation of Co–SnR3 Porphycene Species
    Matsuo, T.; Komatsuzaki, K.; Tsuji, T.; Hayashi, T. J. Pophyrins. Phthalocyanines. 2012, 16, 616-625.

  10. Synthesis of Rhenium(I) Tricarbonyl Complexes with Carbohydrate-Pendant Tridentate Ligands and their Cellular Uptake
    Mikata, Y.; Takahashi, K.; Noguchi, Y.; Naemura, M.; Ugai, A.; Itami, S.; Yasuda, K.; Tamotsu, S.; Matsuo, T.; Storr, T. Eur.J. Inorg. Chem. 2012, 217-225.

  11. Structural Basis for the Transcriptional Regulation of Heme Homeostasis in Lactococcus lactis
    Sawai, H.; Yamanaka, M.; Sugimoto, H.; Shiro, Y.; Aono, S. J. Biol. Chem. 2012, 16, 30755-30768.


Original papers
  1. Supramolecular Organization of Light-Harvesting Porphyrin Macrorings
    Satake, A.; Azuma, S.; Kuramochi, Y.; Hirota, S.; Kobuke, Y. Chem. Eur. J. 2011, 17, 855-865.

  2. Enhancement of Laccase Activity through the Construction and Breakdown of a Hydrogen Bond at the Type I Copper Center in Escherichia coli CueO and the Deletion Mutant Δα5-7 CueO
    Kataoka, K.; Hirota, S.; Maeda, Y.; Kogi, H.; Shinohara, N.; Sekimoto, M.; Sakurai, T. Biochemistry 2011, 50, 558-565.

  3. Post-translational His-Cys Cross-Linkage Formation in Tyrosinase Induced by Copper(II)-Peroxo Species
    Fujieda, N.; Ikeda, T.; Murata, M.; Yanagisawa, S.; Aono, S.; Okubo, K.; Nagao, S.; Ogura, T.; Hirota, S.; Fukuzumi, S.; Nakamura, Y.; Hata, Y.; Itoh, S. J. Am. Chem. Soc. 2011, 133, 1180-1183.

  4. Efficient Reduction of Cys110 Thiyl Radical by Glutathione in Human Myoglobin
    Nagao, S.; Asami, O.; Yasui, H.; Hirota, S. Biochim. Biophys. Acta – Proteins and Proteomics 2011, 1814, 480-486.

  5. Peroxidase Activity Enhancement of Horse Cytochrome c by Dimerization
    Wang, Z.; Matsuo, T.; Nagao, S.; Hirota, S. Org. Biomol. Chem. 2011, 9, 4766-4769.

  6. DNA Cleavage by the Photocontrolled Cooperation of ZnII Centers in an Azobenzene-Linked Dizinc Complex
    Panja, A.; Matsuo, T.; Nagao, S.; Hirota, S. Inorg. Chem. 2011, 50, 11437-11445.

  7. Thermal Isomerization of N-Bridged Cobalt Corrole Complexes through Transiently Formed Axial Carbenoid
    Chattopadhyay, P.; Matsuo, T; Tsuji, T.; Ohbayashi, J.; Hayashi, T. Organometallics 2011, 30, 1869-1873.

  8. Precise Design of Artificial Cofactors for Enhancing Peroxidase Activity of Myoglobin: Myoglobin Mutant H64D Reconstituted with a Single-winged Cofactor is Equivalent to Native Horseradish Peroxidase in Oxidation Activity
    Matsuo, T; Fukumoto, K.; Watanabe, T.; Hayashi, T. Chem. Asian. J. 2011, 6, 2491-2499. [INSIDE COVER FIGURE]
  9. Investigation of Aromaticity and Photophysical Properties in [18]/[20]pi-Porphycene Derivatives
    Kim, K. S.; Sung, Y. M.; Matsuo, T.; Hayashi, T.; Kim, D. Chem. Eur. J. 2011, 17, 7882-7889.
  10. Conferment of Folding Ability to a Naturally Unfolded Apocytochrome c through Introduction of Hydrophobic Amino Acid Residues
    Yamanaka, M; Masanari, M; Sambongi, Y. Biochemistry 2011, 50, 2313-2320.


Original papers
  1. Supramolecular Protein–Protein Complexation via Specific Interaction Between Glycosylated Myoglobin and Sugar-binding Protein
    Nagai, H.; Onoda, A.; Matsuo, T.; Hayashi, T. Supramol. Chem. 2010, 22, 57-64.

  2. Reduction of Bis(dithiolene)oxo(disulfido)tungsten(VI) Complex with Dihydrogen Related to the Chemical Function of the Fourth Tungsten–Containing Enzyme (WOR4) from Pyrococcus furiosus
    Sugimoto, H.; Tano, H.; Toyota, K.; Tajima, R.; Miyake, H.; Takahashi, I.; Hirota, S.; Itoh, S. J. Am. Chem. Soc. 2010, 132, 8-9.

  3. Effect of Heme Modification on Oxygen Affinity of Myoglobin and Equilibrium of the Acid-Alkaline Transition in Metmyoglobin
    Shibata, T.; Nagao, S.; Fukaya, M.; Tai, H.; Nagatomo, S.; Morihashi, K.; Matsuo, T.; Hirota, S.; Suzuki, A.; Imai, K.; Yamamoto, Y. J. Am. Chem. Soc. 2010, 132, 6091-6098.

  4. Coherent Dynamics and Ultrafast Excited State Relaxation of Blue Copper Protein; Plastocyanin
    Nagasawa, Y.; Fujita, K.; Katayama, T.; Ishibashi, Y.; Miyasaka, H.; Takabe, T.; Nagao, S; Hirota, S. Phys. Chem. Chem. Phys. 2010, 12, 6067-6075.

  5. Structural Basis of the Lactate-Dependent Allosteric Regulation of Oxygen Binding in Arthropod Hemocyanin
    Hirota, S.; Tanaka, N.; Micetic, I.; Di Muro, P.; Nagao, S.; Kitagishi, H.; Kano, K.; Magliozzo, R. S.; Peisach, J.; Beltramini, M.; Bubacco, L. J. Biol. Chem. 2010, 285, 19338-19345.

  6. Characterization of the Acid–alkaline Transition in the Individual Subunits of Human Adult and Foetal Methaemoglobins
    Shibata, T.; Nagao, S.; Tai, H.; Nagatomo, S.; Hamada, H.; Yoshikawa, H.; Suzuki, A.; Yamamoto, Y. J. Biochem. 2010, 148, 217-229.

  7. Cytochrome c Polymerization by Successive Domain Swapping at the C-Terminal Helix
    Hirota, S.; Hattori, Y.; Nagao, S. Taketa, M.; Komori, H.; Kamikubo, H.; Wang, Z.; Takahashi, I.; Negi, S.; Sugiura, Y.; Kataoka, M.; Higuchi, Y. Proc. Natl. Acad. Sci. USA 2010, 107, 12854-12859.

  8. Crystallization and Preliminary X-ray Analysis of Dimeric and Trimeric Cytochromes c from horse Heart
    Taketa, M.; Komori, H.; Hattori, Y.; Nagao, S.; Hirota, S.; Higuchi, Y. Acta. Crystallogr. Sect. F 2010, 66, 1477-1479.

  9. New Class of Rhodamine Luminophore: Design, Syntheses and Aggregation-Induced Emission Enhancement
    Kamino, S.; Horio, Y.; Komeda, S.; Minoura, K.; Ichikawa, H.; Horigome, J.; Tatsumi, A.; Kaji, S.; Yamaguchi, T.; Usami, Y.; Hirota, S.; Enomoto, S.; Fujita, Y. Chem. Commun. 2010, 46, 9013-9015.

  10. Oxoferryl Porphyrin/Hydrogen Peroxide System Whose Behavior is Equivalent to Hydroperoxoferric Porphyrin
    Kitagishi, H.; Tamaki, M.; Ueda, T.; Hirota, S.; Ohta, T.; Naruta, Y.; Kano, K. J. Am. Chem. Soc. 2010, 132, 16730–16732.


Original papers
  1. A Role of the Heme-7-Propionate Side Chain in Cytochrome P450cam as a Gate for Regulating the Access of Water Molecules to the Substrate-Binding Site
    Hayashi, T.; Harada, K.; Sakurai, K.; Shimada, H.; Hirota, S. J. Am. Chem. Soc. 2009, 131, 1398-1400.

  2. Four-Electron Reduction of Dioxygen by a Multicopper Oxidase, CueO, and Roles of Asp112 and Glu506 Located Adjacent to the Trinuclear Copper Center
    Kataoka, K.; Sugiyama, R.; Hirota, S.; Inoue, M.; Urata, K; Minagawa, Y.; Seo, D.; Sakurai, T. J. Biol. Chem., 2009 284, 14405-14413.

  3. Modulation of Protein-Ligand Interactions by Photocleavage of a Cyclic Peptide using Phosphatidylinositol 3-Kinase SH3 Domain as Model System
    Takahashi, I.; Kuroiwa, S.; Lindfors, H.; Ndamba, L. A.; Hiruma, Y.; Yajima, T.; Okishio, N.; Ubbink, M.; Hirota, S. J. Petp. Sci. 2009, 15, 411-416.

  4. Electron Transfer from Cytochrome c to Cupredoxin
    Takayama, S. J.; Irie, K.; Tai, H.; Kawahara, T.; Hirota, S.; Takabe, T.; Alcaraz, J. A.; Donaire, A.; Yamamoto, Y. J. Biol. Inorg. Chem. 2009, 14, 821-828.

  5. Regulating Copper-Binding Affinity with Photoisomerizable Azobenzene Ligand by Construction of a Self-Assembled Monolayer
    Takahashi, I; Honda, Y.; Hirota, S. Angew. Chem. Int. Ed. 2009, 48, 6065-6068.

  6. Coordination-induced sliding motion of a complementary porphyrin-phthalocyanine dimer: fluorescence-based molecular switch
    Satake, A.; Sugimura, T.; Kobuke, Y. J. Porphyrins Phthalocyanines 2009, 13, 326-335.

  7. Energy transfer followed by electron transfer in a porphyrin macrocycle and central acceptor ligand: A model for a photosynthetic composite of the light-harvesting complex and reaction center
    Kuramochi, Y.; Sandanayaka, Atula S. D.; Satake, A.; Araki, Y.; Ogawa, K.; Ito, O.; Kobuke, Y. Chem. Eur. J. 2009, 15, 2317-2327.

  8. Single Supramolecular Porphyrin Wires Bridging Gold Nanoparticles
    Satake, A.; Fujita, M.; Kurimoto, Y.; Kobuke, Y. J. Inorg. Chem. 2009, 1231-1233.

  9. Meso-Unsubstituted Iron Corrole in Hemoproteins: Remarkable Differences in Effects on Peroxidase Activities between Myoglobin and Horseradish Peroxidase
    Matsuo, T.; Hayashi, A.; Abe, M.; Matsuda, T.; Hisaeda Y.; Hayashi, T. J. Am. Chem. Soc. 2009, 131, 15124-15125.

Reviews (International achievements only)

  1. Electron Transfer and Oxidation Activities in Reconstituted Hemoproteins with Chemically Modified Cofactor
    Matsuo, T.; Hayashi, T. J. Porphyrins Phthalocyanines 2009, 13, 1082-1089.


Original papers
  1. Evaluation of the Functional Role of the Heme-6-Propionate Side Chain in Cytochrome P450cam
    Harada, K.; Sakurai, K.; Ikemura, K.; Ogura, T.; Hirota, S.; Shimada, H.; Hayashi, T. J. Am. Chem. Soc. 2008, 130, 432-433.

  2. H-atom Abstraction Reaction for Organic Substrates via Mononuclear Copper(II)-Superoxo Species as a Model for DbM and PHM
    Fujii, T.; Yamaguchi, S.; Hirota, S.; Masuda, H. Dalton Trans 2008, 164-170.

  3. Development of Novel Water-Soluble Photocleavable Protective Group and Its Application for Design of Photoresponsive Paclitaxel Prodrugs
    Noguchi, M.; Skwarczynski, M.; Prakash, H.; Hirota, S.; Kimura, T.; Hayashi, Y.; Kiso, Y. Bioorg. Med. Chem. 2008, 16, 5389-5397.

  4. Thermodynamics of Apoplastocyanin Folding: Comparison between Experimental and Theoretical Results
    Yoshidome, T.; Kinoshita, M.; Hirota, S.; Baden, N.; Terazima, M. J. Chem. Phys. 2008, 128, 225104.

  5. Photocontrol of Spatial Orientation and DNA Cleavage Activity of Copper(II)-Bound Dipeptides Linked by an Azobenzene Derivative
    Prakash, H.; Shodai, A.; Yasui, H.; Sakurai, H.; Hirota, S. Inorg. Chem. 2008, 47, 5045-5047.

  6. A Supramolecular Receptor of Diatomic Molecules (O2, CO, NO) in Aqueous Solution
    Kano, K.; Itoh, Y.; Kitagishi, H.; Hayashi, T.; Hirota, S. J. Am. Chem. Soc. 2008, 130, 8006-8015.

  7. Stable Supramolecular Complex of Porphyrin Macroring with Pyridyl and Fullerenyl Ligands
    Zafer, U.; Satake, A.; Kobuke, Y.; Hirota, S. Tetrahedron Lett. 2008, 49, 5484-5487.

  8. Syntheses, Characterization and Reactivities of μ-η2:η2-Disulfidodicopper(II) Complexes with N-Alkylated cis,cis-1,3,5-Triamionocyclohexane Derivatives
    Kajita, Y.; Matsumoto, J.; Takahashi, I.; Hirota, S.; Funahashi, Y.; Ozawa, T.; Masuda, H., Eur. J. Inorg. Chem. 2008, 3977-3986.

  9. A New Class of Sulfido/oxo(dithiolene)–molybdenum(IV) Complexes Derived from Sulfido/Oxo–Bis(tetrasulfido)molydebnum(IV) Anions
    Sugimoto, H.; Suyama, K.; Sugimoto, K.; Miyake, H.; Takahashi, I.; Hirota, S.; Itoh, S. Inorg. Chem. 2008, 47, 10150-10157.

  10. Molecular Basis of the Bohr Effect in Arthropod Hemocyanin
    Hirota, S.; Kawahara, T.; Beltramini, M.; Di Muro, P.; Magliozzo, R. S.; Peisach, J.; Powers, L. S.; Tanaka, N.; Nagao, S.; Bubacco, L. J. Biol. Chem. 2008, 283, 31941-31948.

  11. Construction of Giant Porphyrin Macrorings Self-Assembled from Thiophenylene-Linked Bisporphyrins for Light-Harvesting Antenna
    Fujisawa, K.; Satake, A.; Hirota, S.; Kobuke, Y. Chem. Eur. J. 2008, 14, 10735-10744.

  12. Formation of a Bridged Butterfly-Type μ-η2:η2-Peroxo Dicopper Core Structure with a Carboxylate Group
    Funahashi, Y.; Nishikawa, T.; Wasada-Tsutsui, Y.; Kajita, Y.; Yamaguchi, S.; Arii, H.; Ozawa, T.; Jitsukawa, K.; Tosha, T.; Hirota, S.; Kitagawa, T.; Masuda, H. J. Am. Chem. Soc. 2008, 130, 16444-16445.

  13. Controlled Production of Amyloid β Peptide from a Photo-Triggered, Water-Soluble Precursor "Click Peptide"
    Taniguchi, A.; Skwarczynski, M.; Sohma, Y.; Okada, T.; Ikeda, K.; Prakash, H.; Mukai, H.; Hayashi, Y.; Kimura, T.; Hirota, S.; Matsuzaki, K.; Kiso, Y. ChemBioChem 2008, 9, 3055-3065.

  14. Oxidation of Adamantane Catalysed by Imidazolylporphyrinatoiron(III) Complexes and Structural Studies of 5-Coordinating Iron(III) Porphyrin,
    Miyazaki, Y.; Satake, A.; Kobuke, Y. J. Mol. Cat. A: Chemical 2008, 283, 129-139.

  15. Light-Harvesting Supramolecular Porphyrin Macroring Accommodating a Fullerene–Tripodal Ligand,
    Kuramochi, Y.; Satake, A.; Itou, M.; Ogawa, K.; Araki, Y.; Ito, O.; Kobuke, Y. Chem. Eur. J. 2008, 14, 2827-2841.

  16. Transmembrane Nanopores from Porphyrin Supramolecules
    Satake, A.; Yamamura, M.; Oda, M.; Kobuke, Y. J. Am. Chem. Soc. 2008, 130, 6314-6315.

  17. Recent Advances in Two-photon Photodynamic Therapy
    Ogawa, K.; Kobuke, Y. Curr. Med. Chem. - Anti-Cancer Agents 2008, 8, 269-279.

  18. Stepwise Elongation Effect on the Two-photon Absorption of Self-assembled Butadiyne Porphyrins
    Dy, J. T.; Ogawa, K.; Kamada, K.; Ohta, K; Kobuke, Y. Chem. Commun. 2008, 3411-3413.


Original papers

  1. Structure and Ligand Binding Properties of Myoglobins Reconstituted with Monodepropionated Heme: Functional Role of Each Heme-Propionate Side Chain
    Harada, K.; Makino, M.; Sugimoto, H.; Hirota, S.; Matsuo, T.; Shiro, Y.; Hisaeda, Y.; Hayashi, T. Biochemistry 2007, 46, 9406-9416.

  2. Trapping of a Dopaquinone Intermediate in the TPQ Cofactor Biogenesis in a Copper-containing Amine Oxidase from Arthrobacter globiformis
    Moore, R. H.; Spies, M. A.; Culpepper, M. B.; Murakawa, T.; Hirota, S.; Okajima, T.; Tanizawa, K.; Mure, M. J. Am. Chem. Soc. 2007, 129, 11524-11534.

  3. Thermodynamical Properties of Reaction Intermediates during Apoplastocyanin Folding in Time-Domain
    Baden, N.; Hirota, S.; Takabe, T.; Funasaki, N.; Terazima, M. J. Chem. Phys. 2007, 127, 175103 (12 pages).

  4. A Photochromic Porphyrin-perinaphthothioindigo Conjugate and its Two-photon Absorption Properties
    Dy, J. T.; Maeda, R.; Nagatsuka, Y.; Ogawa, K.; Kamada, K.; Ohta, K.; Kobuke, Y.  Chem. Commun. 2007, 5170-5172.

  5. Syntheses and Properties of Acetylene-linked Bis- and Trisporphyrins toward Two-photon Photodynamic Therapy
    Inaba, Y.; Ogawa, K.; Kobuke, Y. J. Porphyrins Phthalocyanines 2007, 11, 406-417.

  6. Syntheses and Nonlinear Absorption Properties of Conjugated Porphyrin Supramolecules
    Ogawa, K.; Hara, C.; Kobuke, Y. J. Porphyrins Phthalocyanines 2007, 11, 359-367.

  7. Ligand-Induced Interconversion of a Coordination-Organized Porphyrin Dimer: a Potential Fluorescence-based Molecular Memory Monitor,
    Satake, A.; Tanihara, J.; Kobuke, Y. Inorg. Chem. 2007, 46, 9700-9707.

  8. Water-soluble Self-assembled Butadiyne-bridged Bisporphyrin: a Potential Two- Photon Absorbing Photosensitizer for Photodynamic Therapy
    Dy, J.; K. Ogawa, K.; Satake, A.; Ishizumi, A.; Kobuke, Y. Chem. Eur. J. 2007, 13, 3491-3500.

  9. Singlet Oxygen Generation and Photocytotoxicity against Tumor Cell by Two-Photon Absorption
    Ogawa, K.; Dy, J.; Kobuke, Y.; Ogura, S.; Okura, I. Mol. Cryst. Liq. Cryst. 2007, 471, 61-67.

  10. Supramolecular Array of Imizazolylethynyl-zinc-porphyrin,
    Satake, A.; Shoji, O.; Kobuke, Y. J. Organomet. Chem. 2007, 69, 635-644.

  11. Heme Orientational Disorder in Human Adult Hemoglobin Reconstituted with a Ring Fluorinated Heme and Its Functional Consequences
    Nagao S.; Hirai Y.; Kawano S.; Imai K.; Suzuki A.; Yamamoto Y. Biochem. Biophys. Res. Commun. 2007, 354, 681-685.

Reviews (International achievements only)

  1. Assemblies of Porphyrins and Phthalocyanines Showing Strong Electronic Coupling
    Satake A.; Kobuke, Y. Organic and Bioorganic Chemistry,2007, 5, 1679-1691.

  2. Supramolecular Porphyrin Systems by Self-organization for Nano-photonic Device
    Kobuke, Y.; Satake, A.; Ogawa, K. in BOTTOM-UP NANOFABRICATION: Supramolecules, Self-Assemblies, and Organized Films, 2007, Chapter 16, 1-27.



Original papers

  1. Chemical Shifts as a Novel Measure of Interactions between Two Binding Sites of Symmetric Dialkyldimethylammonium Bromides to α-Cyclodextrin
    Funasaki, N.; Ishikawa, S.; Hirota, S. Anal. Chim. Acta 2006, 555, 278-285.

  2. "Click Peptide" Based on the "O-Acyl Isopeptide Method": Control of Aβ1-42 Production from a Photo-Triggered Aβ1-42 Analogue
    Taniguchi, A.; Sohma, Y.; Kimura, M.; Okada, T.; Ikeda, K.; Hayashi, Y.; Kimura, T.; Hirota, S.; Matsuzaki, K.; Kiso, Y. J. Am. Chem. Soc. 2006, 128, 696-697.

  3. Molecular Motions of α-Cyclodextrin on a Dodecyl Chain Studied by Molecular Dynamics Simulations
    Ishikawa, S.; Hirota, S.; Neya, S.; Funasaki, N. Chem. Pharm. Bull. 2006, 54, 528-534.

  4. Kinetic and Structural Studies on the Catalytic Role of the Aspartic Acid Residue Conserved in Copper Amine Oxidase
    Chiu, Y.-C.; Okajima, T.; Murakawa, T.; Uchida, M.; Taki, M.; Hirota, S.; Kim, M.; Yamaguchi, H.; Kawano, Y.; Kamiya, N.; Kuroda, S.; Hayashi, H.; Yamamoto, Y.; Tanizawa, K. Biochemistry 2006, 45, 4105-4120.

  5. Iron Porphyrin-Cyclodextrin Supramolecular Complex as a Functional Model of Myoglobin in Aqueous Solution
    Kano, K.; Kitagishi, H.; Dagallier, C.; Kodera, M.; Matsuo, T.; Hayashi, T.; Hisaeda, Y.; Hirota, S. Inorg. Chem. 2006, 45, 4448-4460.

  6. Micelle Formation of Bile Salts and Zwitterionic Derivative as Studied by Two-Dimensional NMR Spectroscopy
    Funasaki, N.; Fukuba, M.; Hattori, T.; Ishikawa, S.; Okuno, T.; Hirota S. Chem. Phys. Lipids 2006, 142, 43-57.

  7. Conformational Changes during Apoplastocyanin Folding Observed by Photocleavable Modification and Transient Grating
    Hirota, S.; Fujimoto, Y.; Choi, J.; Baden, N.; Katagiri, N.; Akiyama, M.; Hulsker, R.; Ubbink, M.; Okajima, T.; Takabe, T.; Funasaki, N.; Watanabe, Y.; Terazima, M. J. Am. Chem. Soc. 2006, 128, 7551-7558.

  8. Development of First Photoresponsive Prodrug of Paclitaxel
    Skwarczynski, M.; Noguchi, M.; Hirota, S.; Sohma, Y.; Kimura, T.; Hayashi, Y.; Kiso, Y. Bioorg. Med. Chem. Lett. 2006, 16, 4492-4496.

  9. Masking Mechanisms of Bitter Taste of Drugs Studied with Ion Selective Electrodes
    Funasaki, N.; Uratsuji, I.; Okuno, T.; Hirota, S.; Neya, S. Chem. Pharm. Bull. 2006, 54, 1155-1161.

  10. A Myoglobin Functional Model Composed of a Ferrous Porphyrin and a Cyclodextrin Dimer with an Imidazole Linker
    Kano, K.; Kitagishi, H.; Mabuchi, T.; Kodera, M.; Hirota, S. Chem. Asian J. 2006, 1, 358-366.

  11. Reduction of Plastocyanin by Tyrosine-Containing Oligopeptides
    Hirota, S.; Okumura, H.; Kondoh, T.; Funasaki, N.; Takabe, T.; Watanabe, Y. J. Inorg. Biochem. 2006, 100, 1871-1878.

  12. 'Click peptide’: a novel ‘O-acyl isopeptide method’ for peptide synthesis and chemical biology-oriented synthesis of amyloid βpeptide analoguesShoma, Y.; Taniguchi, A.; Yoshiya, T.; Chiyomori, Y.; Fukao, F.; Nakamura, S.; Skwarczynski, M.; Okada, T.; Ikeda, K.; Hayashi, Y.; Kimura, T.; Hirota, S.; Matsuzaki, K.; Kiso, Y. J. Pept. Sci. 2006, 12, 823–828.

  13. Direct Observation of Photoinduced Electron Transfer in Zinc Porphyrin / Zinc Phthalocyanine Composite
    Ito, F.; Ishibashi, Y.; Khan, S. R.; Miyasaka, H.; Kameyama, K.; Morisue, M.; Satake, A.; Ogawa, K.; Kobuke, Y. J. Phys. Chem. A 2006, 110, 12734-12742.

  14. Construction and Photophysical Properties of Self-assembled Linear Porphyrin Arrays
    Ogawa, K.; Kobuke, Y. J. Photochem. Photobiol. C 2006, 7, 1-16.

  15. Single molecular observation of penta- and hexagonic assembly of bisporphyrin on a gold surface
    Satake, A.; Tanaka, H.; Hajjaj, F.; Kawai, T.; Kobuke, Y. Chem. Commun. 2006, 2542-2544.

  16. A Supramolecular Photosynthetic Triad of Slipped Cofacial Porphyrin Dimer, Ferrocene, and Fullerene
    Nakagawa, H.; Ogawa, K.; Satake, A.; Kobuke, Y. Chem. Commun. 2006, 1560-1562.

  17. Assemblies of Supramolecular Porphyrin Dimers in Pentagonal and Hexagonal Arrays Exhibiting Light-Harvesting Antenna Function
    Hajjaj, F.; Yoon, Z. S.; Yoon, M.-C.; Park, J.; Satake, A.; Kim, D.; Kobuke, Y. J. Am. Chem. Soc. 2006, 128, 4612-4623.

  18. Water-Soluble Bis(imidazolylporphyrin) Self-Assemblies with Large Two-Photon Absorption Cross Sections as Potential Agents for Photodynamic Therapy
    Ogawa, K.; Hasegawa, H.; Inaba, Y.; Kobuke, Y.; Inouye, H.; Kanemitsu, Y.; Kohno, E.; Hirano, T.; Ogura, S.; Okura, I. J. Med. Chem. 2006, 49, 2276-2283.

  19. Two-photon Absorption Properties of Conjugated Supramolecular Porphyrins with Electron Donor and Acceptor
    Tanihara, J.; Ogawa, K.; Kobuke, Y. J. Photochem. Photobiol. A 2006, 178, 140-149.

  20. Synthesis of Hexazincporphyrin and Hexaamine Substituted Ru(bipy)3 Complexes for Alternate Self-Assembly by Tritopic Coordinations
    Fukuda, S.; Satake, A.; Kobuke, Y. Thin Solid Films 2006, 499, 263-268.

Review (International achievements only)

  1. 19F NMR Study of b-Type Haemoproteins
    Yamamoto Y; Nagao S.; Suzuki A. Modern Magnetic Resonance, Webb, G. A. Ed., Springer, 2006, pp.527-534.