奈良先端科学技術大学院大学 先端科学技術研究科　物質創成科学領域 ナノ高分子材料研究室

2014年12月31日 付
（※研究室設置前の分）
研究業績(2015-現在)へもどる

（1） 原著論文　【1999-2014】

2014年

1. Hiroharu Ajiro, Tatsuaki Ueyama, Mitsuru Akashi*
   “Temperature Effect on Template Polymerization of Methacrylic Acid Using Stereocomplex Formation on Quartz Crystal Microbalance Substrates”
   J. Polym. Sci. Part A, Polym. Chem., 2014, 52(21), 3032-3036.
2. Hiroharu Ajiro, Mitsuru Akashi*
   “Rapid Photogelation of Amphiphilic Poly(N-vinylacetamide) Bearing Coumarin Moiety in Water and Organic Solvents”
   Chem. Lett., 2014, 43(10), 1613-1615.
3. Kazuya Takemura, Hiroharu Ajiro, Tomoko Fujiwara, Mitsuru Akashi*
   “Oil gels with a chemically cross-linked copolymer of a trimethylene carbonate derivative and L-lactide: preparation and stereocomplex formation within gels”
   RSC Adv., 2014, 4(63), 33462-33465.
4. Hiroharu Ajiro, Yoshikazu Takahashi, Mitsuru Akashi,* Tomoko Fujiwara*
   “Surface Control of Hydrophilicity and Degradability with Block Copolymers Composed of Lactide and Cyclic Carbonate Bearing Methoxyethoxyl Groups”
   Polymer, 2014, 55(16), 3591-3598.
5. Yukie Takemoto, Hiroharu Ajiro, Mitsuru Akashi*
   “Amphiphilic Poly(N-vinylacetamide) Gels Strengthened with Swelling Solvent”
   Macromol. Chem. Phys. 2014, 215(4), 384-390.
6. Giuseppe Tronci, Hiroharu Ajiro, Stephen J. Russell, David J. Wood, Mitsuru Akashi*
   “Tunable Drug-loading Capability of Chitosan Hydrogels with Varied Network Architectures”
   Acta Biomaterialia, 2014, 10(2), 821-830.

2013年

1. Hiroharu Ajiro, Mitsuru Akashi*
   “Interpenetrating Polymer Network Using Amphiphilic Poly(N-vinyl acetamide) and Poly(2-hydroxyethyl methacrylate) to Deactivate Phosphate Ester Compounds”
   Chem. Lett. 2013, 42(12), 1540-1541.
2. Wanpen Tachaboonyakiat, Hiroharu Ajiro, Mitsuru Akashi*
   “Synthesis of a Thermosensitive Polycation by Random Copolymerization of N-vinylformamide and N-vinylbutyramide”
   Polym. J. 2013, 45(9), 971-978.
3. Masumi Maegawa, Hiroharu Ajiro, Daisuke Kamei, Mitsuru Akashi*
   “A Study on Template Effects Using Irregular Porous Isotactic Poly(methyl methacrylate) Films Constructed with Syndiotactic Rich Poly(methacrylic acid) and Isotactic Poly(methyl methacrylate)”
   Polym. J. 2013, 45(9), 898-903.
4. Hiroharu Ajiro, Yi-Ju Hsiao, Hang Thi Tran, Tomoko Fujiwara, Mitsuru Akashi*
   “Thermally Stabilized Poly(lactide)s Stereocomplex with Bio-based Aromatic Groups at Both Initiating and Terminating Chain Ends”
   Macromolecules 2013, 46(13), 5150-5156.
5. Hiroharu Ajiro, Tomoaki Hinoue, Mitsuru Akashi*
   “Inkjet Approaches Contribute to Facile Isotactic Poly(Methyl)/Syndiotactic Poly(Methyl Methacrylate) Stereocomplex Surface Preparation”
   Macromol. Chem. Phys. 2013, 214(14), 1590-1595. [Cover Picture]
6. Pei Cheng Chua*, Malcolm A. Kelland, Hiroharu Ajiro, Fumika Sugihara, Mitsuru Akashi
   “Poly(vinylalkanamide)s as Kinetic Hydrate Inhibitors: Comparison of Poly(N-vinylisobutyramide) with Poly(N-isopropylacrylamide)”
   Energy Fuels, 2013, 27(1), 183-188.
7. Hong Chu, Hiroharu Ajiro, Yoshikazu Takahashi, Mingqing Chen, Mitsuru Akashi*
   “Nanoparticle Fabrication with Biodegradable Block Copolymer Composed of Hydrophilic Poly(trimethylene carbonate) Derivative and Hydrophobic Polylactide”
   Chem. Lett. 2013, 42(1), 74-76.
8. Mitsuru Yokota, Hiroharu Ajiro, Mitsuru Akashi*
   “Transmission Electron Microscopic Observations of the Multilevel Microstructure of Crosslinked Copolymers with Methacrylates and Siloxane Macromer by a Radically Polymerizable Tuning Approach”
   J. Appl. Polym. Sci. 2013, 127(5), 3325-3332.
9. Mitsuru Yokota, Hiroharu Ajiro, Mitsuru Akashi*
   “Effect of Copolymerizing Fluorine-Bearing Monomers on the Relationship Among Internal Structure, Gas Permeability, and Transparency in Copolymer Networks Composed of Methacrylates and Siloxane Macromers”
   J. Appl. Polym. Sci. 2013, 127(1), 535-543.

2012年

1. Hiroharu Ajiro, Yoshikazu Takahashi, Mitsuru Akashi*, Tomoko Fujiwara*
   “Polylactide Block Copolymers using Trimethylene Carbonate with Methoxyethoxy Side Groups for Dual Modifications on Hydrophilicity and Biodegradability”
   Macromol. Biosci. 2012, 12(10), 1315-1320.
2. Hiroharu Ajiro, Chizuru Hongo, Masumi Maegawa, Daisuke Kamei, Sono Sasaki, Hiroaki Ogawa, Hiroyasu Masunaga, Yukie Takemoto, Kazuyuki Horie, Mitsuru Akashi*
   “Structural Nanospace Feature and Substrate Contribution to Maintaining Stable Porosity of Polymer Chain in Layer-by-layer Assembled isotactic Poly(methyl methacrylate) Films”
   Macromolecules 2012, 45(18), 7660-7663.
3. Hiroharu Ajiro, Yi-Ju Hsiao, Tran Han Thi, Tomoko Fujiwara*, Mitsuru Akashi*
   “A Stereocomplex of Poly(lactide)s with Chain End Modification: Simultaneous Resistances to Melting and Thermal Decomposition”
   Chem. Commun. 2012, 48(68), 8478-8480. [Cover Picture]
4. Mitsuru Yokota, Hiroharu Ajiro, Mitsuru Akashi*
   “The Role of Amide Groups in Vinyl Monomers Containing Siloxane Groups for Highly Oxygen Permeable Hydrogels”
   Bull. Chem. Soc. J. 2012, 85(5), 584-591. [Editor’s Choice: Selected Paper]
5. Mitsuru Yokota, Yuko Miwa, Hiroharu Ajiro, Mitsuru Akashi*
   “The Systematic Study on the Microstructure of Crosslinked Copolymers of Siloxane Macromonomer and Methacrylates by Changing Composition and Components”
   Polym. J. 2012, 44(4), 301-305. [Editor’s Choice: Highlighted Paper]
6. Hiroharu Ajiro, Yoshikazu Takahashi, Mitsuru Akashi*
   “Thermosensitive Biodegradable Homopolymer of Trimethylene Carbonate Derivative at Body Temperature”
   Macromolecules 2012, 45(6), 2668-2674.
7. Hiroharu Ajiro, Klaus Beckerle, Jun Okuda, Mitsuru Akashi*
   “Layer-by-Layer Assembly of Partially Sulfonated Isotactic Polystyrene with Poly(vinylamine)”
   Langmuir 2012, 28(12), 5372-5378.
8. Hiroharu Ajiro, Masumi Maegawa, Mitsuru Akashi*
   “Nanospace Preparation by Crosslinking Helical syndiotactic-Poly(methacrylic acid) in Acetonitrile/Water After Stereocomplexation”
   J. Polym. Sci. Part A: Polym. Chem., 2012, 50(8), 1469-1476.
9. Hiroharu Ajiro, Mitsuru Akashi*
   “Radical Polymerization of Novel N-Substituted-N-vinylformamide Derivatives with Bulky Chiral Substituents”
   J. Polym. Sci. Part A: Polym. Chem. 2012, 50(1), 134-141.

2011年

1. Mitsuru Yokota, Naoki Shimoyama, Kazuhiko Fujisawa, Masataka Nakamura, Hiroharu Ajiro, Mitsuru Akashi*
   “Novel method for Surface Modification of Silicone Containing Hydrogel Using Addition Reaction”
   Chem. Lett. 2011, 40(11), 1297-1299.
2. Hiroharu Ajiro, Yukie Takemoto, Mitsuru Akashi*
   “Interpenetrating Polymer Networks of Poly(N-vinylacetamide) and Stimuli Responsive Polymers Applied to Novel Amphiphilic Gel”
   J. Nanosci. Nanotechnol. 2011, 11(8), 7047-7049.
3. Mitsuru Yokota, Masataka Nakamura, Hiroharu Ajiro, Mitsuru Akashi*
   “Synthesis of a Novel Silicone Monomer Bearing Amide Groups to Improve Compatibility with Hydrophilic Vinyl Monomers”
   Chem. Lett., 2011, 40(8), 858-859.
4. Daisuke Kamei, Hiroharu Ajiro, Mitsuru Akashi*
   “Fusion of Porous Isotactic Poly(methyl methacrylate) Thin Films Fabricated on Silica Nanoparticles with Stepwise Stereocomplex Assembly”
   J. Nanosci. Nanotechnol. 2011, 11(3), 2545-2548.

2010年

1. Hiroharu Ajiro, Yukie Takemoto, Mitsuru Akashi, Pei Cheng Chua, Malcolm A. Kelland*
   “A Study of the Kinetic Hydrate Inhibitor Performance of a Series of Poly(N-alkyl-N-vinylacetamide)s”
   Energy Fuels, 2010, 24(12), 6400-6410.
2. Hiroharu Ajiro, Mitsuru Akashi*
   “Cell Proliferation on Stereoregular isotactic- Poly(propylene oxide) as a Bulk Substrate”
   Biomacromolecules 2010, 11(11), 2840-2844.
3. Daisuke Kamei, Hiroharu Ajiro, Mitsuru Akashi*
   “Specific Recognition of Syndiotactic Poly(methacrylic acid) in Porous Isotactic Poly(methyl methacrylate) Thin Films Based on the Effects of Stereoregularity, Temperature, and Solvent”
   J. Polym. Sci. Part A: Polym. Chem.2010, 48(16), 3651-3657.
4. Hiroharu Ajiro, Masumi Maegawa, Mitsuru Akashi*
   “Thermal Stability of Porous it-PMMA Thin Film Obtained by the Extraction of st-PMAA from it-PMMA/st-PMAA Stereocomplex with Layer-by-layer Assembly on Substrate”
   J. Polym. Sci. Part A: Polym. Chem. 2010, 48(15), 3265-3270.
5. Yukie Takemoto, Hiroharu Ajiro, Taka-aki Asoh, Mitsuru Akashi*
   “Fabrication of Surface-Modified Hydrogels with Polyion Complex for Controlled Release”
   Chem. Mater. 2010, 22(9), 2923-2929.
6. Hiroharu Ajiro, Mitsuru Akashi*
   “Nano Grape Formation by isotacitc-Poly(methacrylic acid)-block-poly(butyl acrylate)”
   Macromol. Rapid Commun., 2010, 31(8), 714-717. [Cover Picture]
7. Daisuke Kamei, Hiroharu Ajiro, Mitsuru Akashi*
   “Morphological Changes of Isotactic Poly(methyl methacrylate) Thin Films via Self-organization and Stereocomplex Formation”
   Polym. J. 2010, 42(2), 131-137.
8. Hiroharu Ajiro, Chizuru Hongo, Mitsuru Akashi*
   “Design and Synthesis of N-Vinylacetamide Derivative with Bulky Group by Nucleophilic Substitution Reaction”
   J. Mol. Struct. 2010, 964(1-3), 67-71.

2009年

1. Hiroharu Ajiro, Kathryn L. Peretti, Emil B. Lobkovsky, Geoffrey W. Coates*
   “On the Mechanism of Isospecific Epoxide Polymerization by Salen Cobalt (III) Complexes: Evidence for Solid-state Catalysis”
   Dalton Trans. 2009, (41), 8828-8830.
2. Hiroharu Ajiro, Yukie Takemoto, Taka-aki Asoh, Mitsuru Akashi*
   “Novel Polyion Complex with Interpenetrating Polymer Network of Poly(acrylic acid) and Partially Protected Poly(vinylamine) Using N-Vinylacetamide and N-Vinylformamide”
   Polymer 2009, 50(15), 3503-3507.
3. Hiroharu Ajiro, Daisuke Kamei, Mitsuru Akashi*
   “Mechanistic Studies on Template Polymerization in Porous Isotactic Poly(methyl methacrylate) Thin Films by Radical Polymerization and Postpolymerization of Methacrylate Derivatives”
   Macromolecules 2009, 42(8), 3019-3025.
4. Hiroharu Ajiro, Yukie Takemoto, Mitsuru Akashi*
   “Interpenetrating Polymer Networks of Poly(N-vinylacetamide) and Poly(acrylic acid) Applied to Novel Amphiphilic Drug Release Substrates with Mechanically Modified Strengths”
   Chem. Lett. 2009, 38(4), 368-369.
5. Hiroharu Ajiro, Mitsuru Akashi*
   “Radical Polymerization of Novel N-Substituted-N-vinylacetamides and Regulated Polymer Structure by Bulky Substituents and Menthol Coordination”
   Macromolecules 2009, 42(2), 489-493.
6. Hiroharu Ajiro, Daisuke Kamei, Mitsuru Akashi*
   “Macroporous Silicagel Substrate for Stereoregular Template Polymerization of Methacrylic Acid Using Stereocomplex Assembled Thin Film”
   Polym. J. 2009, 41(1), 90-93. [Cover Picture]
7. Daisuke Kamei, Hiroharu Ajiro, Chizuru Hongo, Mitsuru Akashi*
   “Solvent Effects on Isotactic Poly(methyl methacrylate) Crystallization and Syndiotactic Poly(methacrylic acid) Incorporation in Porous Thin Films Prepared by Stepwise Stereocomplex Assembly”
   Langmuir 2009, 25(1), 280-285.

2008年

1. Hiroharu Ajiro, Daisuke Kamei, Mitsuru Akashi*
   “Methacrylic Acid and Methyl Methacrylate Oligomers Adsorbed to Porous Isotactic Poly(methyl methacrylate) Ultrathin Films and Mechanistic Studies of Living Template Polymerization”
   J. Polym. Sci. Part A: Polym. Chem. 2008, 46(17), 5879-5886.
2. Daisuke Kamei, Hiroharu Ajiro, Chizuru Hongo, Mitsuru Akashi*
   “Dynamics of Polymer Chains in Porous Thin Films Prepared by Layer-by-Layer Assembly of Isotactic Poly(methyl methacrylate) and Syndiotactic Poly(methacrylic acid)”
   Chem. Lett. 2008, 37(3), 332-333.
3. Hiroharu Ajiro, Junji Watanabe, Mitsuru Akashi*
   “Cell Adhesion and Proliferation on Poly(N-vinylacetamide) Hydrogels and Double Network Approaches for Changing Cellular Affinities”
   Biomacromolecules 2008, 9(2), 426-430.

2007年

1. Hiroharu Ajiro, Junji Watanabe, Mitsuru Akashi*
   “Diversification of Nonionic Amphiphilic Poly(N-vinylacetamide) Hydrogels by a Double Network Approach”
   Chem. Lett. 2007, 36(9), 1134-1135.

2005年

1. Kathryn L. Peretti, Hiroharu Ajiro, Claire T. Cohen, Emil B. Lobkovsky, Geoffrey W. Coates*
   “A Highly Active, Isospecific Cobalt Catalyst for Propylene Oxide Polymerization”
   J. Am. Chem. Soc. 2005, 127(33), 11566-11567.

2004年

1. Hiroharu Ajiro, Shigeki Habaue, Yoshio Okamoto*
   “Anionic Polymerization of Novel Styrene Derivatives Bearing Various Amino Groups at ortho-Position”
   Polym. J. 2004, 36(4), 323-328.
2. Shigeki Habaue*, Hiroharu Ajiro, Yasuhiro Yoshii, Tetsuya Hirasa
   “Asymmetric Oxidative Coupling Polymerization Affording Polynaphthylene with 1,1’-Bi-naphthol Units”
   J. Polym. Sci. Part A: Polym. Chem. 2004, 42(18), 4528-4534.
3. Hiroharu Ajiro, Osamu Ikeshima, Shigeki Habaue, Yoshio Okamoto*
   “Immobilization of Vinyl Polymer Chains on Macroporous Silica Gel by Atom Transfer Radical Polymerization and Surface Structure Control”
   Kobunshi Ronbunshu 2004, 61(4), 250-255.

2003年

1. Shigeki Habaue, Tomoaki Seko, Masaya Isonaga, Hiroharu Ajiro, Yoshio Okamoto*
   “Stereoselective Synthesis of (R,R)-, (S,S)-, and (R,S)-Poly(2,3-dihydroxy-1-4-naphthylene) Derivatives by Asymmetric Oxidative Coupling Polymerization”
   Polym. J. 2003, 35(7), 592-597.
2. Kozo Matsumoto, Hiroharu Ajiro, Shigeki Habaue, Yoshio Okamoto*
   “Detection of Inorganic Species by Chemical Reaction Laser Desorption Ionization Mass Spectrometry”
   Rapid Commn. Mass Spectrom. 2003, 17(7), 678-684.

2002年

1. Hiroharu Ajiro, Shigeki Habaue, Yoshio Okamoto*
   “Stereochemistry in Anionic Polymerization of Styrene Derivatives Bearing Optically Active Amino Groups at ortho-Position”
   Polym. J. 2002, 34(2), 57-62.
2. Kozo Matsumoto, Hiroharu Ajiro, Shigeki Habaue, Yoshio Okamoto*
   “Application of TLC-MALDI-TOFMS to Identification of Co(II) and Co(III) Acetylacetonates”
   J. Mass Spectrom. Soc. Jpn. 2002, 50(1), 15-17.
3. Kozo Matsumoto, Hiroharu Ajiro, Shigeki Habaue, Yoshio Okamoto*
   “Detection of Solid Cobalt Species by MALDI-TOF-MS”
   Rapid Commun. Mass Spectrom. 2002, 16(7), 730-732.

2001年

1. Kozo Matsumoto, Hiroharu Ajiro, Shigeki Habaue, Yoshio Okamoto*
   “Modifications of TLC-MALDI-TOFMS for Lower Detection Limits Comparable with Conventional MALDI-TOFMS”
   J. Mass Spectrom. Soc. Jpn. 2001, 49(3), 127-132.
2. Shigeki Habaue, Osamu Ikeshima, Hiroharu Ajiro, Yoshio Okamoto*
   “Surface Structure Control of Macroporous Silica Gel by Atom Transfer Radical Polymerization”
   Polym. J. 2001, 33(11), 902-905.

2000年

1. Shigeki Habaue, Hiroharu Ajiro, Yoshio Okamoto*
   “Anionic Polymerization of o-Substituted Styrene Derivatives: Control of Reactivity and Stereochemistry by Aminomethyl Group”
   J. Polym. Sci. Part A: Polym. Chem. 2000, 38(22), 4088-4094.

1999年

1. Kozo Matsumoto, Shigeki Habaue, Hiroharu Ajiro, Yoshio Okamoto*
   “Application of TLC-MALDI/TOFMS to Identification of Unknown Mixtures Produced in an Organic Synthetic Process”
   J. Mass Spectrom. Soc. Jpn. 1999, 47(4), 274-280.

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（2） 著書・総説・総合論文など 【1999-2014】

1. Mitsuru Akashi, Hiroharu Ajiro
   “Template Polymerization (molecular templating)”
   Encyclopedia of Polymeric Nanomaterials. Springer. Editors: Shiro Kobayashi, Klaus Müllen. accepted on August 28th 2014.
2. 網代広治
   “Essays バイオマテリアルの夢を語る- 連携とアウフヘーベン”
   バイオマテリアル, 32巻2号、page134．発行日2014年4月.
3. 竹本友紀恵, 網代広治, 明石 満
   “第1章 徐放のための材料. 1. 高分子 ②合成高分子(非吸収性)”
   ここまで広がるドラッグ徐放技術の最前線－古くて新しいドラッグデリバリーシステム(DDS), 遺伝子医学MOOK. pp. 40-44. 発行日2013年3月20日．編集 田畑泰彦.　出版 株式会社メディカル ドゥ. 発行人 大上 均. 編集部 小早川久美.
4. Michiya Matsusaki, Hiroharu Ajiro, Toshiyuki Kida, Takeshi Serizawa, Mitsuru Akashi
   “LbL Asesmbly Through Weak Interactions and Their Biomedical Applications”
   Adv. Mater. 2012, 24(4), 454-474.
5. Hiroharu Ajiro, Peter C. B. Widger, Syud M. Ahmed, Scott D. Allen, Geoffrey W. Coates
   “Stereoselective Ring-Opening Polymerization of Epoxides”
   In Polymer Science: A Comprehensive Reference, Chapter 4.; Matyjaszewski, K.,　Möller, M., Eds.; Elsevier: Amsterdam, 2012; 165−181.
6. Takeshi Serizawa, Mitsuru Akashi, Michiya Matsusaki, Hiroharu Ajiro, Toshiyuki Kida
   “LbL Assemblies Using van der Waals or Affinity Interaction and Their Applications”
   G. Decher and J. Schlenoff Eds., Multilayer Thin Films Sequential Assembly of Nanocomposite Materials, 2nd Edition (Wiley-VCH, Verlag GmbH & Co. KGaA, Weinheim, Germany), 2012, 99-133.
7. 網代広治, 明石 満
   “第4編 第2章 第3節 ポリマーゲル”
   ラジカル重合ハンドブック, pp. 741-747. 発行日2010年9月10日．監修者 蒲池幹治，遠藤剛，岡本佳男，福田猛．発行者 吉田隆．発行所 株式会社エヌ・ティー・エス．編集 有限会社 新日本編集企画．印刷製本 新日本印刷株式会社．ISBN 978-4-86043-274-4．
8. Hiroharu Ajiro, Yukie Takemoto, Taka-aki Asoh, Mitsuru Akashi
   “Simple Polyion Complex Hydrogel by Poly(acrylic acid) and Partially Protected Poly(vinylamine)” 高分子 59巻7号, Hot Topics, pp.461．発行日2010年7月1日．発行 社団法人 高分子学会．印刷 日本印刷株式会社．ISSN 0454-1138.
9. 網代広治, 明石 満
   “ポリ(N-ビニルアミド誘導体)の構造制御”
   未来材料 9巻4号, pp.38-44．発行日2009年4月10日．編集人 遠藤剛．発行人 吉田隆．発行所 株式会社エヌ・ティー・エス．印刷所 三美印刷株式会社．ISBN 978-4-86043-177-8．
10. Hiroharu Ajiro, Scott D. Allen, Geoffrey W. Coates
    “Discrete Catalysts for Stereoselective Epoxide Polymerization”
    Editors: Baugh, Lisa S.; Canich, Jo Ann M. Stereoselective Polymerization with Single-Site Catalysts, 2008, 627-644. Publisher: CRC Press LLC, Boca Raton, New York.

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（3） 特許 【1999-2014】

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• 特願2014-151364
• 特願2013-135035, WO2014208604（A１）
• 特願2013-079141, PCT/JP2014/059222, WO2014163012A1
• 特願2012-109797, WO2013/108884
• 特願2011-101393, 特開2012-232909
• 特願2008-518292, 特表2008-546785
• 特願2007-144642, 特願2007-60031, 特開2008-255313
• EP1901845(A0), EP1901845(A2), EP1901845(A3), CA2612547(A1), CA2612547（C）, US2006293501(A1), US7399822(B2), WO2007002023(A3)