The Bio-processing Engineering Laboratory organized by Prof. Hosokawa promotes developmental research on high-precision and fast manipulation methodologies for biological materials, such as cells and proteins, in which state-of-the-art laser technology is combined with microscopic manipulation and detection technologies. Especially we have the world’s top facilities and activities on cell manipulation and processing by femtosecond laser amplifier and have attracted attention as a pioneer of laser applications for biotechnology.
Research（Jump to past research）
开发高通量细胞分选仪
利用飞秒激光聚焦在水中产生的高速冲击力，我们建立了可对流经细胞进行高速分选的系统。
超薄柔性平板玻璃材料加工技术及其应用的发展
通过使用飞秒激光技术，我们开发了一种超薄玻璃加工方法。极短的脉冲可以避免热效应，进而实现材料的高精度加工。
细胞粘附评估
我们旨在通过分析飞秒激光撞击过程中细胞的分离行为，进而建立一种在分子水平上评估附着力的方法
阐明细胞对机械刺激的生理反应和功能运作
我们将阐明激光照射的参数（脉冲能量，频率，焦点与细胞之间的距离等）与其诱导的细胞生理响应的关系，并开发用于时空控制细胞功能技术。
使用飞秒激光将分子引入细胞
我们正在使用飞秒激光将各种分子引入组织中的单个细胞，并试图开发一种控制其功能的方法。Past research（Jump to present research）
Quantification of impulse
Quantification femtosecond laser-induced impulsive force.Appl.Phys.Express. 3:107002(2010).
Adhesion between animal cells
Noncontact estimation of intercellular adhesion strengthProc. Natl. Acad. Sci. USA 108(2011).
Adhesion in plant cell
Quantification of adhesion strength between sub-organelles inside plant cellNat. Plants 1, 15035 (2015).
Photoporation
Delivery of biomolecules into targeted single cells in living vertebrate embryosPLoS ONE Vol. 6, No. 11(2011).
Stiffness of biological tissue
Precise evaluation of stiffness of micro-sized biological objectAppl. Phys. Express 7, 087002 (2014).
